An analysis of sex differences, opioids and nociception in a TMEV mouse model of Multiple Sclerosis
Principle Scientist, Biologics Toxicology, Janssen Pharmaceutical
Undergraduate Institution and Major/Degree:
Cornell College, Biochemistry and Molecular Biology
- Alvin Beitz, Ph.D.
- Moses K. Njenga, Ph.D. / MD
Multiple Sclerosis (MS) is one of the most common neurological diseases of young adults in Europe and North America. Worldwide, approximately 2.5 million people are affected by this chronic inflammatory, demyelinating disease of the CNS. Symptoms of multiple sclerosis include sensory disturbances, trunk and limb paresthesias, limb weakness and gait ataxia. Intracranial inoculation of Theiler's murine encephalomyelitis virus (TMEV) into susceptible strains of mice produces a biphasic disease in which the chronic phase models human multiple sclerosis. My research focuses on three main areas: (1) gender differences in disease progression, (2) pain in multiple sclerosis and (3) interactions between chemokine and opiate receptors and how they affect the progression of the disease.
- Bill Engeland
- Alice Larson
- M.K. Njenga
- Alvin Beitz
Courses Taken Beyond the Core Courses:
- MVB 8201 - Mechanisms of Animal Health and Disease
- NSC 8026 - Neuro-immune interactions
- NSC 8222 - Central Regulation of Autonomic Function
- PE 1015 - Weight Training
- PUBH 5414 - Biostatistical Methods I
- WOST 3202 - Biology of Women
- GRAD 8101 - Teaching in higher education
- MICA 8001 - Integrated topics
- PHCL 8208 - Neuropsychopharmacology
- MICA 8003 - Immunity and Immunopathology
- PHCL 8207 - Seminar - Psychopharmacology
Conferences Attended and Presentations:
- Society for Neuroscience annual meeting - Fall 2001, 2003, 2004 (presented posters 2003 and 2004 listed under presentations)
- Society on Neuroimmune Pharmacology - spring 2004 did not present
- David Brown - Chair
- Philip Peterson
- Mike Murtaugh
- Alvin Beitz - Advisor
- M. K. Njenga - Advisor
- AK Ali, WA banks, CV Kumar, CN Shah, JL Lynch, Farr SA, MA Feegal-DeMotta, JE Morley. Nitric oxide activity and isoenzyme expression in the senescence-accelerated mouse p8 model of Alzheimer’s disease: effects of anti-amyloid antibody and antisense treatments. Journal of Gerontology Series A. 2009 Oct. 64 (10) 1025-30.
- LB Jaeger, S Dohgu, MC Hwang, SA Farr, MP Murphy, MA Fleegal-Demotta, JL Lynch, SM Robinson, ML Niehoff, SN Johnson, VB Kuma, WA Banks. Testing the neurovascular hypothesis of Alzheimer’s disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition. Journal of Alzheimers Disease. 2009 Jul; 17(3)553-70
- LB Jaeger, S Dohgu, R Sultana, JL Lynch, JB Owen, MA Erickson, GN Shah, TO Price, MA Fleegal-DeMotta, DA Butterfield, WA Banks. Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer's disease. Brain Behavior and Immunity. 2009 May; 23(4) 507-17
- E Elinav, L Niv-Spector, M Katz, Price TO, M Ali, M Yacobovitz, G Solomon, S Reicher, JL Lynch, Z Halpern, WA Banks, A Gertler. Pegylated leptin antagonist is a potent orexigenic agent: preparation and mechanism of activity. Endocrinology. 2009 Jul; 150(7):3083-91
- JL Lynch. An analysis of sex differences, opioids and nociception in a TMEV mouse model of Multiple Sclerosis. PhD Thesis; University of Minnesota, 2006.
- JL Lynch, JF Alley, L Wellman, MK Njenga, AJ Beitz. Decreased opiate receptor expression and opiate analgesia in the TMEV mouse model of Multiple Sclerosis. Brain Res. 2008 Jan 29; 1191:180-91.
- Banks WA, Dohgu S, Lynch JL, Fleegal-DeMotta MA, Erickson MA, Nakaoke R, Vo TQ. Nitric Oxide isoenzymes regulate lipopolysaccharide-enhanced insulin transport across the blood-braid barrier. Endocrinology. 2008 Apr; 149(4):1514-23.
- JL Lynch, N Gallus, ME Ericson, AJ Beitz. Analysis of nociception, sex and peripheral nerve innervation in the TMEV animal model of multiple sclerosis. Pain. 2008 Jun; 136(3):293-304.
- JL Lynch and William A Banks. Vairable Effects of Acute and Chronic Morphine Treatment and Withdrawal on Blood-to-brain transport of I1-2, IL-1α and TFN α. Brain Behav Immun. 2008 22(7):1096-102.
- Salkini MA, Lynch JL, Otamis-Price T, Banks WA. Lipopolysaccharide Impairs Blood-Brain Barrier P-glycoprotein Function in Mice Through Prostaglandin- and Nitric Oxide-Independent Pathways. J Neuroimmune Pharmacol. 2008 Nov 28
Awards and Honors:
- Lin Graduate Student Fellowship, 2004
- PharmacoNeuroImmunology Training Fellowship, University of Minnesota, 2003-present
- Beta Beta Beta Biological Honor Society, Cornell College 1998-2001
- Motor Board, Cornell College 2000-2001
- Biochemistry Molecular Biology Outstanding Senior, Cornell College, 2000-2001
- Deans List, Cornell College , fall 1998-2000, spring 1998 -2001
- Iowa Intercollegiate Athletic Conference Academic All-Conference, softball 2000
- National Fast pitch Coaches Association All-American Scholar Athlete, 2000
- Society for Neuroscience
- Society on Neuroimmune Pharmacology
- Walla Walla, Washington
- High School - DeSales Catholic