Jennifer Zick

Ph.D. 2018

Member of MSTP (MD/PhD) program

Thesis Title:

Effective Disconnection of Intrinsic Networks in the Prefrontal Cortex: Convergence across Primate and Mouse Models of Schizophrenia

Undergraduate Institution and Major:

University of Minnesota, B.S. in Neuroscience, 2009

Current Position:

Resident, Department of Psychiatry (PSTP program), University of Minnesota

Previous Position(s):

Medical School, University of Minnesota

Graduate Level Publications:

  • Redish AD, Kepecs A, Anderson LM, Calvin OL, Grissom NM, Haynos AF, Heilbronner SR, Herman AB, Jacob S, Ma S, Vilares I, Vinogradov S, Walters CJ, Widge AS, Zick JL, Zilverstand A. Computational validity: using computation to translate behaviours across species. Philos Trans R Soc Lond B Biol Sci. 2022 Feb 14;377(1844):20200525.
  • Zick JL, Crowe DA, Blackman RK, Schultz K, Bergstrand DW, DeNicola AL, Carter RE, Ebner TJ, Lanier LM, Netoff TI, Chafee MV. Disparate insults relevant to schizophrenia converge on impaired spike synchrony and weaker synaptic interactions in prefrontal local circuits. Curr Biol. 2021 Oct 20:S0960-9822(21)01363-4.
  • Zick JL, Camchong J, Redish AD, Vinogradov SV. Circuit Psychiatry: Non-Drug Therapeutic Interventions for Impaired Neural System Functioning. In: AB Niculescu III, J Licinio (Eds.), Translational Neuroscience in Psychiatry. Oxford University Press. 2019.
  • Zick JL, Blackman RK, Crowe DA, Amirikian B, DeNicola AL, Netoff TI, Chafee MV. Blocking NMDAR disrupts spike timing and decouples monkey prefrontal circuits: implications for activity-dependent disconnection in Schizophrenia. Neuron. 2018 Jun 27;98(6):1243-1255.
  • Zick JL, Blackman RK, Chafee MV, Netoff T. Application of generalized linear models to investigate functional synaptic coupling and synchrony in an animal model of schizophrenia. BMC Neurosci. 2015;16(suppl 1):P175.
  • MacDonald III AW, Zick JL, Chafee MV, Netoff TI.  Integrating insults: Using fault tree analysis to guide schizophrenia research across levels of analysis.  Front Hum Neurosci. 2016 Jan 6;9:698.

Graduate Level Abstracts:

  • Zick JL, Blackman RK, Chafee MV, Netoff TI. Application of generalized linear models to investigate functional synaptic coupling and synchrony in an animal model of Schizophrenia.  Annual Meeting of the Organization for Computational Neuroscience; Prague, Czech Republic, 2015.
  • Zick JL, Blackman RK, Chafee MV, Netoff TI. Analysis of spike timing and functional coupling in a non-human primate model of schizophrenia. Annual Meeting of the Society for Neuroscience; Chicago, IL, 2015.
  • Zick JL,  Tariq  N,  Strom  NA,  Vazquez  G,  Rodriguez  G,  Divani  AA.  Assessment of measurement techniques for degree of stenosis of carotid artery. 61st Annual Meeting of the American Academy of Neurology. Seattle, WA. April 25-May 2, 2009. 

Professional Presentations:

  • Changes in Cellular-Level Functional Connectivity across Primate and Mouse Models of Schizophrenia. Oral presentation at Department of Neuroscience Colloquium Series, University of Minnesota, Minneapolis, MN, June 22, 2016.
  • Disordered cellular interactions in prefrontal local circuits across animal models of schizophrenia. MSTP monthly student meeting GS3 research presentation. March 21, 2016.
  • Neuronal Network Dynamics in a Primate Model of Schizophrenia.  Oral presentation at Department of Neuroscience Colloquium Series, University of Minnesota, Minneapolis, MN, May 20, 2015.

Rotations:

  • Theoden Netoff, Ph.D., Department of Biomedical Engineering
  • Theresa Nick, Ph.D., Department of Neuroscience

Professional Outreach:

  • Brain Awareness Week Instructor, 2014

Graduate Co-Advisors:

Thesis Committee Members:

Description of Graduate Research:

My research involves characterizing abnormalities in neuronal network dynamics in animal models of schizophrenia. I conduct multielectrode neural recordings in awake mice and use computational model simulations to investigate changes in spike synchrony and functional coupling between neighboring prefrontal cortical neurons.

Research Areas:

  • Behavioral and Cognitive Neuroscience
  • Computational Neuroscience
  • Neuropsychiatric Disease

Graduate Level Awards and Honors:

  • Morris Smithberg Memorial Prize, 2014
  • American Legion Brain Sciences Award, 2016

 

Jennifer Zick