Daniel Schuster

Ph.D. 2013

 

Thesis Title:

Investigating intrathecal adeno-associated virus vectors for the study of analgesic interactions at the spinal level

Current Position:

Study Director, Medtronic

Undergraduate Institution and Major/Degree:

  • University of Minnesota/Neuroscience and Psychology

Major Advisor(s):

Committee Members:

  • Bill Elmquist - Chair
  • Scott McIvor
  • Lucy Vulchanova
  • George Wilcox - Co-Advisor
  • Carolyn Fairbanks - Co-Advisor

Lab Rotations:

  • Carolyn Fairbanks
  • George Wilcox
  • Robert Elde

Courses Taken Beyond the Core Courses:

  • PHM 8481  - Advanced Neuropharmaceutics
  • PHM 8120  - Readings in CNS Drug Delivery
  • PHCL 5462 - Neuroscience Principles of Drug Abuse
  • PHCL 5110 - Intro to Pharmacology

Conferences Attended:

  • World Congress on Pain - 2012
  • American Pain Society annual meeting - 2012
  • Midwest Pain Interest Group - 2011
  • Society for Neuroscience annual meeting - 2007, 2009, 2010, 2011, 2012

Publications:

  • Schuster DJ, Metcalf MD, Kitto KF, Messing RO, Fairbanks CA, Wilcox GL. Ligand requirements for involvement of protein kinase-C epsilon in synergistic analgesic interactions between mu- and delta-opioid receptors. Br J Pharmacol. 2015;172(2):388-402.
  • Chabot-Dore A-J, Schuster DJ, Stone LS, Wilcox GL. Analgesic synergy between opioid and alpha-2 adrenergic receptors. Br J Pharmacol. 2015;172(2):388-402.
  • Schuster DJ, Dykstra JA, Riedl MS, Kitto KF, Belur LR, McIvor RS, Elde RF, Fairbanks CA, Vulchanova L. Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse. Front Neuroanat. 2014 Jun 10;8:42.
  • Schuster DJ, Belur LR, Riedl MS, Schnell SA, Podetz-Pedersen KM, Kitto KF, McIvor RS, Vulchanova L, Fairbanks CA. Supraspinal gene transfer by intrathecal adeno-associated virus serotype 5. Front Neuroanat. 2014 Aug 5;8:66. 
  • Schuster DJ, Kitto KF, Overland AC, Messing RO, Stone LS, Fairbanks CA, Wilcox GL. Protein kinase C-epsilon is required for spinal analgesic synergy between delta opioid and alpha-2A adrenergic receptor agonist pairs. J Neurosci. 2013;33(33):13538-46.
  • Schuster DJ, Dykstra JA, Riedl MS, Kitto KF, McIvor RS, Honda CN, Fairbanks CA, Vulchanova L. Visualization of spinal afferent innervation in the mouse colon by AAV8-mediated GFP expression. Neurogastroenterol Motil. 2013;25(2):e89-100.
  • Vulchanova L, Schuster DJ, Belur LR, Riedl MS, Podetz-Pedersen KM, Kitto KF, Wilcox GL, McIvor RS, Fairbanks CA. Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture. Mol Pain. 2010 May 28;6:31.
  • Wade CL, Schuster DJ, Domingo KM, Kitto KF, Fairbanks CA. Supraspinally-administered agmatine attenuates the development of oral fentanyl self-administration. Eur J Pharmacol. 2008;587(1-3):135-40.

Abstracts/Presentations:

  • Daniel J. Schuster, Matthew D. Metcalf, Kelley F. Kitto, Aaron C. Overland, Laura S. Stone, Robert O. Messing, Carolyn A. Fairbanks, George L. Wilcox. The mechanism underlying spinal analgesic synergy between delta and mu opioid receptors depends on the agonist combination used. Society for Neuroscience, October 2012.
  • Daniel J. Schuster, Kelley F. Kitto, Stephen A. Schnell, Aaron C. Overland, Laura S. Stone, Robert O. Messing, Carolyn A. Fairbanks, George L. Wilcox. The requirement of Protein Kinase C-epsilon for spinal analgesic synergy specifically indicates a signaling interaction at the level of the pre-synaptic primary afferent terminal. International Association for the Study of Pain, 14th World Congress On Pain, August 2012.
  • Daniel J. Schuster, Stephen A. Schnell, Kelley F. Kitto, Aaron C. Overland, Laura S. Stone, Robert O. Messing, Carolyn A. Fairbanks, George L. Wilcox. Immunohistochemical evaluation of immunoreactivity for Protein Kinase C-epsilon in dorsal root ganglia and spinal cord. American Pain Society, 31st Annual Scientific Meeting, May 2012.
  • Daniel J. Schuster, Kelley F. Kitto, Aaron C. Overland, Laura S. Stone, Carolyn A. Fairbanks, George L. Wilcox. Separation of Synergistic Analgesic Opioid/Adrenergic Interactions By The Requirement of Protein Kinase C-Epsilon. Society for Neuroscience, November 2011.
  • Daniel J. Schuster, Lucy Vulchanova, Maureen Riedl, Lalitha Belur, R. Scott McIvor, Kelley Kitto, Kelly Podetz-Pedersen, Cece Baum, George L. Wilcox, Carolyn A. Fairbanks. Gene-Delivery Across Spinal Levels After Intrathecal AAV5 or AAV8. Midwest Pain Interest Group, July 2011.
  • Daniel J. Schuster, Lucy Vulchanova, Maureen Riedl, Lalitha Belur, R. Scott McIvor, Kelley Kitto, Kelly Podetz-Pedersen, George L. Wilcox, Carolyn A. Fairbanks. Gene-Transfer To The Central Nervous System By AAV5 Delivered Via Direct Lumbar Puncture. Society for Neuroscience, November 2010.
  • Lucy Vulchanova, Daniel J. Schuster, Maureen Riedl, Lalitha Belur, R. Scott McIvor, Carolyn A. Fairbanks. Visualization of spinal afferent nerve fibers in the colon. Society for Neuroscience, November 2010.
  • Daniel J. Schuster, Lucy Vulchanova, Maureen Riedl, Lalitha Belur, R. Scott McIvor, Kelley F. Kitto, Kelly Podetz-Pedersen, George L. Wilcox, Carolyn A. Fairbanks. Intrathecal AAV5- and AAV8-Mediated Gene Delivery to Spinal Cord and Dorsal Root Ganglia. Society for Neuroscience. October 2009.

Awards and Honors:

  • 3M Science and Technology Fellowship 2007-2011
  • Ruth L. Kirschstein National Research Service Award - 2009
  • Morris Smithberg Memorial Prize - 2007-2008
  • World Congress on Pain Travel Award - 2012
  • American Pain Society Young Investigator Travel Award - 2012
  • Stark Award for Advanced Scholarship - 2011
  • GPN Milne-Brandenburg Award - 2009
  • Poppele Prize - 2009

Home Town:

  • Maple Grove, MN
Daniel Schuster