Magnetoencephalography (MEG) is a noninvasive brain imaging method with very high temporal resolution and good spatial resolution. Weaknesses of MEG include low signal-to-noise ratio and difficulty in the interpretation of complex patterns of signal. Many systems level responses remain difficult to interpret because of these weaknesses. My work includes efforts to interpret these responses where currently available tools have fallen short: there remain many questions in systems-level functional brain imaging that are easy to ask but difficult to answer. The result of the work is the development and use of approaches to recording and analysis of data that fall outside standard methods.
Current interests include long term learning, variability in brain response due to many factors, and improved characterization of responses to simple stimuli or multimodal stimuli.
(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
Sakellaridi S, Christova P, Christopoulos V, Leuthold AC, Peponis J, Georgopoulos AP. Neural mechanisms underlying the exploration of small city maps using magnetoencephalography. Exp Brain Res. 2015 Aug 8.
James LM, Belitskaya-Lévy I, Lu Y, Wang H, Engdahl BE, Leuthold AC, Georgopoulos AP. Development and application of a diagnostic algorithm for posttraumatic stress disorder. Psychiatry Res. 2015 Jan 30;231(1):1-7.
Tan H-RM, Leuthold AC, Lee DN, Lynch JK, Georgopoulos AP. Neural mechanisms of movement speed and tau as revealed by magnetoencephalography. Exp Brain Res. 2009 Jun;195(4):541-52. Epub 2009 May 8.
Georgopoulos AP, Karageorgiou E, Leuthold AC, Lewis SM, Lynch JK, Alonso AA, Aslam Z, Carpenter AF, Georgopoulos A, Hemmy LS, Koutlas IG, Langheim FJ, McCarten JR, McPherson SE, Pardo JV, Pardo PJ, Parry GJ, Rottunda SJ, Segal BM, Sponheim SR, Stanwyck JJ, Stephane M, Westermeyer JJ. Synchronous neural interactions assessed by magnetoencephalography: a functional biomarker for brain disorders. J Neural Eng. 2007 Dec;4(4):349-355.
Wilson TW, Leuthold AC, Moran JE, Pardo PJ, Lewis SM, Georgopoulos AP. Reading in a deep orthography: neuromagnetic evidence for dual-mechanisms. Exp Brain Res. 2007 Jun;180(2):247-62.
Langheim FJ, Leuthold AC, Georgopoulos AP. Synchronous dynamic brain networks revealed by magnetoencephalography. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):455-9.
Langheim FJ, Merkle AN, Leuthold AC, Lewis SM, Georgopoulos AP. Dipole analysis of magnetoencephalographic data during continuous shape copying. Exp Brain Res. 2006 Apr;170(4):513-21.
Wilson TW, Leuthold AC, Lewis SM, Georgopoulos AP, Pardo PJ. Cognitive dimensions of orthographic stimuli affect occipitotemporal dynamics. Exp Brain Res. 2005 Nov;167(2):141-7.
Georgopoulos AP, Langheim FJ, Leuthold AC, Merkle AN. Magnetoencephalographic signals predict movement trajectory in space. Exp Brain Res. 2005 Nov;167(1):132-5.
Leuthold AC, Langheim FJ, Lewis SM, Georgopoulos AP. Time series analysis of magnetoencephalographic data during copying. Exp Brain Res. 2005 Aug;164(4):411-22.
Wilson TW, Leuthold AC, Lewis SM, Georgopoulos AP, Pardo PJ. The time and space of lexicality: a neuromagnetic view. Exp Brain Res. 2005 Mar;162(1):1-13.
Former Graduate Students:
Fred Langheim (Ph.D. 2004, Neuroscience, University of Minnesota).