The skin and deep tissues comprise a vital interface between our bodies and our surroundings. The senses of touch and pain are especially critical in interactions with our environment. Our research interests are centered on functional and structural mechanisms underlying these senses, and there is a particular emphasis in our laboratory on neuronal mechanisms contributing to the sensory experience of pain.
We use a combination of anatomical, immunohistochemical, and electrophysiological techniques to establish basic relationships between neuronal structure, cytochemistry and function. We are applying these techniques to the study of individual sensory neurons of the peripheral nervous system. Currently, our main research direction is the functional regulation of peripheral opioid receptors, and how these receptors contribute to peripheral analgesic systems.
(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
Brederson JD, Honda CN. Primary afferent neurons express functional delta opioid receptors in inflamed skin. Brain Res. 2015 Jul 21;1614:105-11.
Abdelhamid RE, Kovács KJ, Honda CN, Nunez MG, Larson AA. Resiniferatoxin (RTX) causes a uniquely protracted musculoskeletal hyperalgesia in mice by activation of TRPV1 receptors. J Pain. 2013 Dec;14(12):1629-41
Schuster DJ, Dykstra JA, Riedl MS, Kitto KF, Honda CN, McIvor RS, Fairbanks CA, Vulchanova L. Visualization of spinal afferent innervation in the mouse colon by AAV8-mediated GFP expression. Neurogastroenterol Motil. 2013 Feb;25(2):e89-100.
Davidson S, Zhang X, Khasabov SG, Moser HR, Honda CN, Simone DA, Giesler GJ Jr. Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate. J Neurophysiol. 2012 Sep;108(6):1711-23. Epub 2012
Waataja, J, Twedon, K, and Honda, CN. Effects of high frequency alternating current on axonal conduction through the vagus nerve. J Neural Eng. 2011 Oct;8(5):056013. Epub 2011.
Schramm CL, Honda CN. Co-administration of δ- and μ-opioid receptor agonists promotes peripheral opioid receptor function. Pain. 2010 Dec;151(3):763-70.
Riedl MS, Braun PD, Kitto KF, Roiko SA, Anderson LB, Honda CN, Fairbanks CA, Vulchanova L. Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing. J Neurosci. 2009 Oct 21;29(42):13377-88.
Wenk HN, Brederson JD, Honda CN. Morphine directly inhibits nociceptors in inflamed skin. J Neurophysiol. 2006 Apr;95(4):2083-97.
Simone DA, Zhang X, Li J, Zhang JM, Honda CN, LaMotte RH, Giesler GJ Jr. Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli. J Neurophysiol. 2004 Jan;91(1):213-22.
Truong H, McGinnis L, Dindo L, Honda CN, Giesler GJ Jr. Identification of dorsal root ganglion neurons that innervate the common bile duct of rats. Exp Brain Res. 2004 Apr;155(4):477-84.
Wenk HN, Nannenga MN, Honda CN. Effect of morphine sulphate eye drops on hyperalgesia in the rat cornea. Pain. 2003 Oct;105(3):455-65.
Wenk HN, Honda CN. Silver nitrate cauterization: characterization of a new model of corneal inflammation and hyperalgesia in rat. Pain. 2003 Oct;105(3):393-401.
Former Graduate Students:
Catherine Satterfield (Ph.D. 2008, Neuroscience, University of Minnesota).
Cicely Schramm (Ph.D. 2010, Neuroscience, University of Minnesota).
Heather Wenk (Ph.D. 2002, Neuroscience, University of Minnesota).