Neuronal networks, diversity, and specificity of function are important to both physiological processes and neurological disorders, including epilepsy. My laboratory seeks to improve our understanding of how cells interact within a network, how networks interact with each other, and the physiological roles of neuronal populations. In this regard, key questions remain in epilepsy research, including what are the principal networks, conditions, and cell types involved in initiating, sustaining, propagating, terminating, and potentially suppressing, seizures. By improving our understanding of these, we improve the prospects of someday reaching the goal of no seizures, no side effects, for all epilepsy patients. My lab uses rodent models of neurological disorders, including temporal lobe epilepsy, and techniques including electrophysiology, optogenetics, immunocytochemistry, transgenic animals, and behavioral experiments to address these fundamental questions.
(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
Krook-Magnuson E, Gelinas J, Soltesz I, Buzsaki G. "Neuroelectronics and bio-optics: Closed-loop technologies in neurological disorders." JAMA Neurology. 2015 Jul 1;72(7):823-9.
Nagaraj V, Lee S, Krook-Magnuson E, Soltesz I, Benquet P, Irazoqui P, Netoff T. "Future of Seizure Prediction and Intervention: Closing the loop." Journal of Clinical Neurophysiology. 2015 Jun;32(3):194-206.
Krook-Magnuson E, Armstrong C, Bui A, Lew S, Oijala M, Soltesz I. "In Vivo Evaluation of the Dentate Gate Theory in Epilepsy. " Journal of Physiology. (2015)
Krook-Magnuson E and Soltesz I "Beyond the hammer and the scalpel: selective circuit control for the epilepsies." Nature Neuroscience 18, 331–338 (2015)
Krook-Magnuson E, Szabo G, Armstrong C, Oijala M, Soltesz I "Cerebellar Directed Optogenetic Intervention Inhibits Spontaneous Hippocampal Seizures in a Mouse Model of Temporal Lobe Epilepsy" eNeuro 2014.
Krook-Magnuson E, Ledri M, Soltesz I, Kokaia M. "How might novel technologies such as optogenetics lead to better treatments in epilepsy?" Adv Exp Med Biol. 2014;813:319-36.
Armstrong C, Krook-Magnuson E, Oijala M, Soltesz I. "Closed-loop optogenetic intervention in mice." Nat Protoc. 2013 Aug;8(8):1475-93.
Krook-Magnuson E, Armstrong C, Oijala M, Soltesz I. "On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy." Nat Commun. 2013;4:1376.
Armstrong C, Krook-Magnuson E, Soltesz I. "Neurogliaform and Ivy Cells: A Major Family of nNOS Expressing GABAergic Neurons." Front Neural Circuits. 2012 May 16;6:23.
Krook-Magnuson E, Varga C, Lee SH, Soltesz I. "New dimensions of interneuronal specialization unmasked by principal cell heterogeneity." Trends Neurosci. 2012 Mar;35(3):175-84.
Krook-Magnuson E, Luu L, Lee SH, Varga C, Soltesz I. "Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation." J Neurosci. 2011 Oct 19;31(42):14861-70.
Krook-Magnuson EI, Li P, Paluszkiewicz SM, Huntsman MM. "Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex." J Neurophysiol. 2008 Aug;100(2):932-44.
Krook-Magnuson E, Huntsman MM. "The transience of interneuron circuit diversity just "sped" up." Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16723-4. Epub 2007 Oct 15.
Krook-Magnuson EI, Huntsman MM. "Excitability of cortical neurons depends upon a powerful tonic conductance in inhibitory networks." Thalamus Relat Syst. 2005 Jun;3(2):115-120.
Current Graduate Students:
Zoe Christenson Wick (Neuroscience, University of Minnesota)
Zachary Zeidler (Neuroscience, University of Minnesota)