Lab Website: http://www.ghoselab.cmrr.umn.edu
I am interested in how cognitive phenomena, such as learning and attention, affect the neuronal signals underlying visually guided behaviors. My laboratory studies striate and extrastriate areas of visual cortex in monkeys that have been trained to perform sophisticated visuo-motor tasks. Extracellular activity on single and multiple neurons is related to behavioral performance while the animals perform these tasks. These studies will be complemented by a direct study of neuronal populations using both intrinsic optical imaging techniques as well as functional magnetic resonance. One line of study involves studying the neuronal basis of perceptual learning in the cerebral cortex. Monkeys are trained for many months to perform a difficult visual discrimination task and the potential physiological correlates of the trained behavioral improvement are studied (Ghose et al, 2002).
The second area of research addresses how strategies acquired during the course of training affect neuronal signals and visual performance. Although animals are sensitive to task timing and form temporal representations automatically there has been very little study of how timing strategies affect visual processing. Although there is evidence that task timing directly affects visual responses (Ghose and Maunsell, 2002) it is unclear how universal these affects are. It is also possible that behavioral strategies alter the relationship between individual neuronal activity and the performance of the animal. Because such strategies are automatically formed during any repetitive task, characterizing the effects of such strategies is critical for understanding the neuronal basis of perception and decision making.
Current projects in this area involve simultaneous measurements of neuronal activity and behavior in a challenging task whose demands very over time in a consistent manner. As with the perceptual learning project, a key aspect of the strategy project is the modeling how the signals from individual neurons are integrated and interpreted to form a percept and ultimately guide behavior.
(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
- Dowdle LT, Ghose G, Chen CCC, Ugurbil K, Yacoub E, Vizioli L. Statistical power or more precise insights into neuro-temporal dynamics? Assessing the benefits of rapid temporal sampling in fMRI. Prog Neurobiol. 2021 Sep 4:102171.
- Dowdle LT, Ghose G, Ugurbil K, Yacoub E, Vizioli L. Clarifying the role of higher-level cortices in resolving perceptual ambiguity using ultra high field fMRI. Neuroimage. 2021 Feb 15;227:117654.
- Krause BM, Ghose GM. Micropools of reliable area MT neurons explain rapid motion detection. J Neurophysiol. 2018;120(5):2396-2409.
- Ghose GM, Ts'o DY. Integration of color, orientation, and size functional domains in the ventral pathway. Neurophotonics. 2017 Jul;4(3):031216.
- McLoon LK, Christiansen SP, Ghose GM, Das VE, Mustari MJ. Improvement of eye alignment in adult strabismic monkeys by sustained IGF-1 treatment. Invest Ophthalmol Vis Sci. 2016;57:6070-6078.
- Weiner KF, Ghose GM. Population coding in area V4 during rapid shape detections. J Neurophysiol. 2015;113:3021-3034.
- Ghose GM. Vision and vigilance on the go. Trends Cogn Sci. 2015 Mar;19(3):115-6.
- Warren SG, Yacoub E, Ghose GM. Featural and temporal attention selectively enhance task-appropriate representations in human primary visual cortex. Nat Commun. 2014 Dec 12;5:5643.
- Weiner KF, Ghose GM. Rapid shape detection signals in area V4. Front Neurosci. 2014 Sep 16;8:294.
- Harrison IT, Weiner KF, Ghose GM. Inattention blindness to motion in middle temporal area. J Neurosci. 2013;33:8396-410.
- Schneider BA, Ghose GM. Temporal production signals in parietal cortex. PLoS Biol. 2012;10(10):e1001413.
Current Graduate Students:
Former Graduate Students:
Elisabeth Moore (Ph.D. 2019, Neuroscience, University of Minnesota).
Scott Warren (Ph.D. 2016, Neuroscience, University of Minnesota).
Katherine Weiner (Ph.D. 2014, Neuroscience, University of Minnesota)
Blaine Schneider (Ph.D. 2011, Neuroscience, University of Minnesota).