Research in my laboratory is directed towards gaining an integrative understanding of the role of the central nervous system in the long-term regulation of arterial pressure and the pathogenesis of hypertension. At the present time we are investigating how circulating hormones, such as angiotensin II and aldosterone, are monitored by specialized sites within the brain called circumventricular organs. We are investigating how these regions influence ongoing sympathetic nerve discharge and ultimately the regulation of arterial pressure. Our long-term goal is to understand, in a quantitative way, the role of such hormonal-sympathetic interactions in normal physiology and the pathophysiology of hypertension. Specifically, we are studying how such interactions are influenced by alterations in dietary salt in hopes of understanding the neurogenic basis of salt-dependent hypertension. A variety of experimental approaches are employed to address these issues including state-of-the-art long-term monitoring of cardiovascular hemodynamics and direct measurement of sympathetic nerve discharge in awake animals. We have also initiated a collaborative project with the Department of Mathematics to begin developing new mathematical models of how the nervous system regulates cardiovascular function over long periods of time.
In addition to the work in my own laboratory, I am the coordinator for a newly formed national research effort to study the role of the brain in cardiovascular diseases. "The Neurogenic Cardiovascular Diseases Consortium" is a novel NIH funded project which joins 5 major research Universities to investigate neurogenic cardiovascular diseases at all levels of regulation; gene, single cell, neural networks and whole animal. This work will be carried out by Universities of Minnesota (home institution), Pittsburgh, Texas-San Antonio, Florida-Gainesville and Michigan State University.
(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
Foss, J.D., Fink, G.D. and Osborn, J.W. Differential role of afferent and efferent renal nerves in the maintenance of early and late phase Dahl S hypertension. Am J Physiol, in press, 2015.
Annoni EM, Xie X, Lee SW, Libbus I, KenKnight BH, Osborn JW, Tolkacheva EG. Intermittent electrical stimulation of the right cervical vagus nerve in salt-sensitive hypertensive rats: effects on blood pressure, arrhythmias, and ventricular electrophysiology. Physiol Rep. 2015 Aug;3(8).
Han R, Wang X, Bachovchin W, Zukowska Z, Osborn JW. Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation. Sci Rep. 2015 Aug 5;5:12348.
Xiao L, Kirabo A, Wu J, Saleh MA, Zhu L, Wang F, Takahashi T, Loperena R, Foss JD, Mernaugh RL, Chen W, Roberts J 2nd, Osborn JW, Itani HA, Harrison DG. Renal Denervation Prevents Immune Cell Activation and Renal Inflammation in Angiotensin II-Induced Hypertension. Circ Res. 2015 Aug 28;117(6):547-57.
Averina VA, Othmer HG, Fink GD, Osborn JW. A mathematical model of salt-sensitive hypertension: the neurogenic hypothesis. J Physiol. 2015 Jul 15;593(14):3065-75.
Foss JD, Wainford RD, Engeland WC, Fink GD, Osborn JW. A novel method of selective ablation of afferent renal nerves by periaxonal application of capsaicin. Am J Physiol Regul Integr Comp Physiol. 2015 Jan 15;308(2):R112-22.
Averina VA, Othmer HG, Fink GD, Osborn JW. A mathematical model of salt-sensitive hypertension: the neurogenic hypothesis. J Physiol. 2014 Sep 12.
Kuroki MT, Fink GD, Osborn JW. Comparison of arterial pressure and plasma ANG II responses to three methods of subcutaneous ANG II administration. Am J Physiol Heart Circ Physiol. 2014 Sep 1;307(5):H670-9. doi: 10.1152/ajpheart.00922.2013. Epub 2014 Jul 3.
Osborn JW, Hendel MD, Collister JP, Ariza-Guzman PA, Fink GD. The role of the subfornical organ in angiotensin II-salt hypertension in the rat. Exp Physiol. 2012 Jan;97(1):80-8. Epub 2011 Oct 3.
Kuroki MT, Ariza-Guzman PA, Fink GD, Osborn JW. Time Dependent Changes in Autonomic Control of Splanchnic Vascular Resistance and Heart Rate in AngII-Salt Hypertension. Am J Physiol Heart Circ Physiol. 2011 Nov 23.
Xie X, Visweswaran R, Guzman PA, Smith RM, Osborn JW, Tolkacheva EG. The effect of cardiac sympathetic denervation through bilateral stellate ganglionectomy on electrical properties of the heart. Am J Physiol Heart Circ Physiol. 2011 Jul;301(1):H192-9. Epub 2011 Apr 15.
Osborn JW, Fink GD, Kuroki MT. Neural mechanisms of angiotensin II-salt hypertension: implications for therapies targeting neural control of the splanchnic circulation. Curr Hypertens Rep. 2011 Jun;13(3):221-8.
Osborn JW, Fink GD. Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. The kidney is not always the target in neurogenic hypertension. J Appl Physiol. 2010 Dec;109(6):2008.
Veitenheimer B, Osborn JW. Role of spinal V1a receptors in regulation of arterial pressure during acute and chronic osmotic stress. Am J Physiol Regul Integr Comp Physiol. 2011 Feb;300(2):R460-9. Epub 2010 Dec 1.
Abrams JM, Engeland WC, Osborn JW. Effect of intracerebroventricular benzamil on cardiovascular and central autonomic responses to DOCA-salt treatment. Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1500-10. Epub 2010 Oct 6.
Toney GM, Pedrino GR, Fink GD, Osborn JW. Does enhanced respiratory-sympathetic coupling contribute to peripheral neural mechanisms of angiotensin II-salt hypertension? Exp Physiol. 2010 May;95(5):587-94. Epub 2010 Mar 12.
Yoshimoto M, Miki K, Fink GD, King A, Osborn JW. Chronic angiotensin II infusion causes differential responses in regional sympathetic nerve activity in rats. Hypertension. 2010 Mar;55(3):644-51. Epub 2010 Jan 25.
Osborn JW, Fink GD. Region-specific changes in sympathetic nerve activity in angiotensin II-salt hypertension in the rat. Exp Physiol. 2010 Jan;95(1):61-8. Epub 2009 Aug 28.
Former Graduate Students:
Marcos Kuroki (Ph.D. 2013, Neuroscience, University of Minnesota).
Britta Veitenheimer (Ph.D. 2012, Neuroscience, University of Minnesota).
Joanna Abrams (Ph.D. 2008, Neuroscience, University of Minnesota).
John P. Collister, D.V.M, Ph.D. 1999. Graduate program in Molecular Veterinary Biosciences. Dissertation: "Angiotensin-sympathetic interactions in the long-term control of arterial pressure". Current Position: Research Associate, Department of Veterinary PathoBiology, University of Minnesota.
David P. Slovut, M.D., Ph.D. 1998. Graduate Program in Cellular and Integrative Physiology. Dissertation: "Mechanisms of heart rate variablity after cardiac allograft transplantation. Current Position: Cardiology Fellow, University of Michigan.
Scott Carlson, Ph.D. 1996. Graduate Program in Cellular and Integrative Physiology. Dissertation: "The role of peripheral osmoreceptors in the control of arginine vasopressin release". Current Position: Assistant Professor, Luther College.