- Cognitive neuroscience of higher cognitive functions and mental disorders
- Neuroimaging of brain physiology
- Application of high performance computing to biomedicine
- Application of brain imaging to psychiatry and neurosurgery
Dr. Pardo leads a research program which seeks to elucidate the functional architecture of the human brain with particular emphasis on how dysfunction within neural networks relates to psychiatric disorders. The multidisciplinary approach (in close collaboration with the Brain Sciences Center, Department of Psychology, Department of Psychiatry, and GRECC) involves methods from cognitive neuroscience, including several imaging modalities, particularly fMRI and PET. Brain systems under study in normal subjects include attention and its involvement in memory and affect; language processing and applications to preoperative neurosurgical assessment; and emotional processing through mood induction by cognitive and sensory stimuli. Clinical protocols currently underway seek to relate pathophysiology to the evolving neuroanatomy of the mind. Patient populations include those with mood disorders, schizophrenia, and post traumatic stress disorder.
(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
Pardo, J.V., Fahnhorst, S.A., Lee, J.T., Kusksowski, M.A., Eberly, R.E., Engdahl, B.E. Human brain functional plasticity with recovery from trauma: Combat veterans with pure active vs. remitted PTSD. Human Brain Mapp (2014), in revision.
Charles Schulz S, Camchong J, Romine A, Schlesinger A, Kuskowski M, Pardo JV, Cullen KR, Lim KO. An exploratory study of the relationship of symptom domains and diagnostic severity to PET scan imaging in borderline personality disorder. Psychiatry Res. 2013 Nov 30;214(2):161-8.
Larson AA, Pardo JV, Pasley JD. Review of overlap between thermoregulation and pain modulation in fibromyalgia. Clin J Pain. 2014 Jun;30(6):544-55.
Pardo JV. Mania following addition of hydroxytryptophan to monoamine oxidase inhibitor. Gen Hosp Psychiatry. 2012 Jan-Feb;34(1):102.e13-4.
Jerde, T.A., Krejcarek S., Handy, S.T., Nagode, J.C., Pardo, J.V. Dissociable systems of working memory for rhythm and melody. Neuroimage 1572-1579 (2011).
White, T., Moeller, S., Schmidt, M., Pardo, J.V., Olman, C. Evidence for intact local connectivity but disrupted regional function in the occipital lobe in children and adolescents with schizophrenia. Hum Brain Mapp (early view; first appeared Jun 14, 2011).
Pardo JV, Lee JT, Kuskowski MA, Munch KR, Carlis JV, Sheikh SA, Surerus C, Lewis SM, McCarten JR, Fink H, McPherson S, Shah HH, Rottunda S, Dysken MW. Fluorodeoxyglucose positron emission tomography of mild cognitive impairment with clinical follow-up at 3 years. Alzheimers Dement. 2010 Jul;6(4):326-33. Epub 2010 May 6.
Pardo, J.V., Lee, J.T., Kuskowski, M.A., Surerus, C., Hagen, M.H., McPherson, S., McCarten, J.R., Rottunda, S., Dysken, M. Fluorodeoxyglucose positron emission tomography of mild cognitive impairment with clinical follow-up at 3 years. Alz & Dementia 6:326-333 (2010).
Spoont, M.R., Kuskowski, M.A., Pardo, J.V. Autobiographical memories of anger in violent and non-violent individuals: A script-driven imagery study. Psychiat Res- Neuroim 183:225-229 (2010).
Lee, J.T., Munch, K.R., Carlis, J.V., Pardo, J.V. Internet Image Viewer: iiV. BMC Med Imag 8:10 (2008).
Pardo, J.V., Sheikh, S.A., Schwindt, G.C., Lee, J.T., Kuskowski, M.A., Surerus-Johnson, C., Lewis, S.M., Abuzzahab, F.S., Hagen, M.C., Adson, D., Rittberg, B. Chronic vagal nerve stimulation of treatment-resistant depression decreases ventromedial prefrontal glucose metabolism. Neuroimage 40:879-889 (2008).
Georgopoulos AP, Karageorgiou E, Leuthold AC, Lewis SM, Lynch JK, Alonso AA, Aslam Z, Carpenter AF, Georgopoulos A, Hemmy LS, Koutlas IG, Langheim FJ, McCarten JR, McPherson SE, Pardo JV, Pardo PJ, Parry GJ, Rottunda SJ, Segal BM, Sponheim SR, Stanwyck JJ, Stephane M, Westermeyer JJ. Synchronous neural interactions assessed by magnetoencephalography: a functional biomarker for brain disorders. J Neural Eng. 2007 Dec;4(4):349-355. Epub 2007 Aug 27.
Munch KR, Carlis JV, Pardo JV, Lee JT. Bringing functional brain image analysis to the clinician: Initial assessment of an online interactive diagnostic aide. Comput Biol Med. 2007 Nov 15;
Pardo JV, Sheikh SA, Kuskowski MA, Surerus-Johnson C, Hagen MC, Lee JT, Rittberg BR, Adson DE. Weight loss during chronic, cervical vagus nerve stimulation in depressed patients with obesity: an observation. Int J Obes (Lond). 2007 Nov;31(11):1756-9. Epub 2007 Jun 12.
Pardo JV, Lee JT, Sheikh SA, Surerus-Johnson C, Shah H, Munch KR, Carlis JV, Lewis SM, Kuskowski MA, Dysken MW. Where the brain grows old: decline in anterior cingulate and medial prefrontal function with normal aging. Neuroimage. 2007 Apr 15;35(3):1231-7. Epub 2007 Jan 25.
Former Graduate Students:
Matthew Hagen (Ph.D. 2004, Neuroscience, University of Minnesota).
Jennifer Nagode (Ph.D. 2002, Neuroscience, University of Minnesota).