Jose V. Pardo, M.D., Ph.D.

Professor, Department of Psychiatry

E-MAIL: jvpardo@james.psych.umn.edu

LAB WEBSITE

Research Interests:

  • Cognitive neuroscience of higher cognitive functions and mental disorders
  • Neuroimaging of brain physiology
  • Application of high performance computing to biomedicine
  • Application of brain imaging to psychiatry and neurosurgery

Dr. Pardo leads a research program which seeks to elucidate the functional architecture of the human brain with particular emphasis on how dysfunction within neural networks relates to psychiatric disorders. The multidisciplinary approach (in close collaboration with the Brain Sciences Center, Department of Psychology, Department of Psychiatry, and GRECC) involves methods from cognitive neuroscience, including several imaging modalities, particularly fMRI and PET. Brain systems under study in normal subjects include attention and its involvement in memory and affect; language processing and applications to preoperative neurosurgical assessment; and emotional processing through mood induction by cognitive and sensory stimuli. Clinical protocols currently underway seek to relate pathophysiology to the evolving neuroanatomy of the mind. Patient populations include those with mood disorders, schizophrenia, and post traumatic stress disorder.


Selected Publications:

(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

  • Pardo JV, Lee JT.  Atypical Localization and Dissociation between Glucose Uptake and Amyloid Deposition in Cognitively Normal APOE*E4 Homozygotic Elders Compared with Patients with Late-Onset Alzheimer's Disease. eNeuro. 2018 Jan-Feb;5(1). PMID: 29497704 
  • Fatemi SH, Wong DF, Brašić JR, Kuwabara H, Mathur A, Folsom TD, Jacob S, Realmuto GM, Pardo JV, Lee S. Metabotropic glutamate receptor 5 tracer [18F]-FPEB displays increased binding potential in postcentral gyrus and cerebellum of male individuals with autism: a pilot PET study. Cerebellum Ataxias. 2018 Feb 12;5:3.
  • Pardo JV, Lee JT, Larson RC, Thuras P, Larson AA. Automated quantitation of cold-inducible human brown adipose tissue with FDG PET/CT with application to fibromyalgia. Am J Nucl Med Mol Imaging. 2017;7(1):24-32
  • Pardo JV. Adjunctive vagus nerve stimulation for treatment-resistant bipolar disorder: managing device failure or the end of battery life. BMJ Case Rep. 2016 Mar 7;2016.
  • Larson AA, Pardo JV, Pasley JD. Review of overlap between thermoregulation and pain modulation in fibromyalgia. Clin J Pain. 2014;30(6):544-55.
  • Charles Schulz S, Camchong J, Romine A, Schlesinger A, Kuskowski M, Pardo JV, Cullen KR, Lim KO. An exploratory study of the relationship of symptom domains and diagnostic severity to PET scan imaging in borderline personality disorder. Psychiatry Res. 2013;214(2):161-8.
  • Larson AA, Pardo JV, Pasley JD. Review of overlap between thermoregulation and pain modulation in fibromyalgia. Clin J Pain. 2014;30(6):544-55.
  • Pardo JV. Mania following addition of hydroxytryptophan to monoamine oxidase inhibitor. Gen Hosp Psychiatry. 2012;34(1):102.e13-4.
  • White T, Moeller S, Schmidt M, Pardo JV, Olman C. Evidence for intact local connectivity but disrupted regional function in the occipital lobe in children and adolescents with schizophrenia. Hum Brain Mapp. 2012;33:1803-11.
  • Jerde TA, Childs SK, Handy ST, Nagode JC, Pardo JV. Dissociable systems of working memory for rhythm and melody. Neuroimage. 2011;57(4):1572-9
  • Pardo JV, Lee JT, Kuskowski MA, Munch KR, Carlis JV, Sheikh SA, Surerus C, Lewis SM, McCarten JR, Fink H, McPherson S, Shah HH, Rottunda S, Dysken MW. Fluorodeoxyglucose positron emission tomography of mild cognitive impairment with clinical follow-up at 3 years. Alzheimers Dement. 2010;6:326-333.
  • Spoont MR, Kuskowski MA, Pardo JV. Autobiographical memories of anger in violent and non-violent individuals: A script-driven imagery study. Psychiat Res Neuroim 2010;183:225-229.
  • Lee JT, Munch KR, Carlis JV, Pardo JV. Internet Image Viewer: iiV. BMC Med Imaging. 2008 May 29;8:10.
  • Pardo JV, Sheikh SA, Schwindt GC, Lee JT, Kuskowski MA, Surerus C, Lewis SM, Abuzzahab FS, Adson DE, Rittberg BR. Chronic vagal nerve stimulation of treatment-resistant depression decreases ventromedial prefrontal glucose metabolism. Neuroimage 2008;40:879-889.
  • Georgopoulos AP, Karageorgiou E, Leuthold AC, Lewis SM, Lynch JK, Alonso AA, Aslam Z, Carpenter AF, Georgopoulos A, Hemmy LS, Koutlas IG, Langheim FJ, McCarten JR, McPherson SE, Pardo JV, Pardo PJ, Parry GJ, Rottunda S, Segal B, Sponheim SR, Stanwyck JJ, Stephane M, Westermeyer JJ. Synchronous neural interactions assessed by magnetoencephalography: a functional biomarker for brain disorders. J Neural Eng. 2007;4:349-55.
  • Munch KR, Carlis JV, Pardo JV, Lee JT. Bringing functional brain image analysis to the clinician: Initial assessment of an online interactive diagnostic aide. Comput Biol Med. 2008;38(2):155-64.
  • Pardo JV, Sheikh SA, Kuskowski MA, Surerus-Johnson C, Hagen MC, Lee JT, Rittberg BR, Adson DE. Weight loss during chronic, cervical vagus nerve stimulation in depressed patients with obesity: an observation. Int J Obes (Lond). 2007;31(11):1756-9.
  • Pardo JV, Lee JT, Sheikh SA, Surerus-Johnson C, Shah H, Munch KR, Carlis JV, Lewis SM, Kuskowski MA, Dysken MW. Where the brain grows old: decline in anterior cingulate and medial prefrontal function with normal aging. Neuroimage. 2007;35(3):1231-7.

Former Graduate Students:

Matthew Hagen (Ph.D. 2004, Neuroscience, University of Minnesota).

Jennifer Nagode (Ph.D. 2002, Neuroscience, University of Minnesota).

Jose Pardo