Matthew Chafee, Ph.D.

Assistant Professor, Department of Neuroscience


Research Interests:

Neural basis of spatial cognition and working memory, cortical system dysfunction in psychiatric disease

Selected Publications:

(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

Blackman RK, Crowe DA, DeNicola AL, Sakellaridi S, MacDonald AW 3rd, Chafee MV. Monkey Prefrontal Neurons Reflect Logical Operations for Cognitive Control in a Variant of the AX Continuous Performance Task (AX-CPT). J Neurosci. 2016 Apr 6;36(14):4067-79.

Elshaikh AA, Sponheim SR, Chafee MV, MacDonald AW. Spatial attentional control is not impaired in schizophrenia: Dissociating specific deficits from generalized impairments. J Abnorm Psychol. 2015 May;124(2):302-8.

Crowe DA, Goodwin SJ, Blackman RK, Sakellaridi S, Sponheim SR, MacDonald AW 3rd, Chafee MV. Prefrontal neurons transmit signals to parietal neurons that reflect executive control of cognition. Nat Neurosci. 2013 Oct;16(10):1484-91.

Blackman RK, Macdonald AW 3rd, Chafee MV. Effects of ketamine on context-processing performance in monkeys: a new animal model of cognitive deficits in schizophrenia. Neuropsychopharmacology. 2013 Oct;38(11):2090-100.

Chafee MV, Crowe DA. Thinking in spatial terms: decoupling spatial representation from sensorimotor control in monkey posterior parietal areas 7a and LIP. Front Integr Neurosci. 2013 Jan 25;6:112.

Chafee MV. A scalar neural code for categories in parietal cortex: representing cognitive variables as "more" or "less". Neuron. 2013 Jan 9;77(1):7-9.

Goodwin SJ, Blackman RK, Sakellaridi S, Chafee MV. Executive control over cognition: stronger and earlier rule-based modulation of spatial category signals in prefrontal cortex relative to parietal cortex. J Neurosci. 2012 Mar 7;32(10):3499-515.

Kang SS, Sponheim SR, Chafee MV, MacDonald AW 3rd. Disrupted functional connectivity for controlled visual processing as a basis for impaired spatial working memory in schizophrenia. Neuropsychologia. 2011 Aug;49(10):2836-47.

Crowe DA, Averbeck BB, Chafee MV. Rapid sequences of population activity patterns dynamically encode task-critical spatial information in parietal cortex. J Neurosci. 2010 Sep 1;30(35):11640-53.

Crowe DA, Averbeck BB, Chafee MV. Neural ensemble decoding reveals a correlate of viewer- to object-centered spatial transformation in monkey parietal cortex. J Neurosci. 2008 May 14.

Chafee MV, Averbeck BB, Crowe DA. Representing spatial relationships in posterior parietal cortex: single neurons code object-referenced position. Cereb Cortex. 2007 Dec;17(12):2914-32.

Chafee MV, Ashe J. Intelligence in action.Nat Neurosci. 2007 Feb;10(2):142-3.

MacDonald AW 3rd, Chafee MV. Translational and developmental perspective on N-methyl-D-aspartate synaptic deficits in schizophrenia. Dev Psychopathol.
2006 Summer;18(3):853-76.

Crowe DA, Averbeck BB, Chafee MV, Georgopoulos AP. Dynamics of parietal neural activity during spatial cognitive processing. Neuron. 2005 Sep 15;47(6):885-91.

Chafee MV, Crowe DA, Averbeck BB, Georgopoulos AP. Neural correlates of spatial judgement during object construction in parietal cortex. Cereb Cortex. 2005 Sep;15(9):1393-413.

Averbeck BB, Chafee MV, Crowe DA, Georgopoulos AP. Parietal representation of hand velocity in a copy task.J Neurophysiol. 2005 Jan;93(1):508-18.

Crowe D.A., Chafee MV, Averbeck B.B., Georgopoulos A.P., (2004) Neural activity related to spatial analysis of visual mazes.  Cerebral Cortex 14:23-34.

Averbeck B.B., Chafee MV, Crowe D.A., Georgopoulos A.P. (2002) Parallel processing of serial movements in prefrontal cortex.  Proceedings of the National Academy of Sciences 99:13172-7.

Current Graduate Students:

Min-Yoon Park (Neuroscience, University of Minnesota).

Adele DeNicola  (Neuroscience, University of Minnesota).

Former Graduate Students:

Rachael Blackman (Ph.D. 2013, Neuroscience, University of Minnesota).

Matthew Chafee