Matthew Chafee, Ph.D.

Professor, Department of Neuroscience


Research Interests:

Neural basis of spatial cognition and working memory, cortical system dysfunction in psychiatric disease

Selected Publications:

(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

  • Kummerfeld E, Ma S, Blackman RK, DeNicola AL, Redish AD, Vinogradov S, Crowe DA, Chafee MV. Cognitive control rrrors in nonhuman primates resembling those in schizophrenia reflect opposing effects of NMDA receptor blockade on causal interactions between cells and circuits in prefrontal and parietal cortices. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020;5(7):705-714.
  • DeNicola AL, Park MY, Crowe DA, MacDonald AW 3rd, Chafee MV. Differential roles of MD thalamus and prefrontal cortex in decision making and state representation in a cognitive control task measuring deficits in schizophrenia. J Neurosci. 2020;40(8):1650-1667.
  • Heilbronner SR, Chafee MV. Learning How neurons fail inside of networks: Nonhuman primates provide critical data for psychiatry. Neuron. 2019;102(1):21-26.
  • Zick JL, Blackman RK, Crowe DA, Amirikian B, DeNicola AL, Netoff TI, Chafee MV. Blocking NMDAR disrupts spike timing and decouples monkey prefrontal circuits: implications for activity-dependent disconnection in Schizophrenia. Neuron. 2018;98(6):1243-1255.
  • Kang SS, MacDonald AW 3rd, Chafee MV, Im CH, Bernat EM, Davenport ND, Sponheim SR.  Abnormal cortical neural synchrony during working memory in schizophrenia.  Clin Neurophysiol. 2018;129:210-221.
  • Kang SS, MacDonald AW 3rd, Chafee MV, Im CH, Bernat EM, Davenport ND, Sponheim SR. Abnormal cortical neural synchrony during working memory in schizophrenia. Clin Neurophysiol. 2018;129(1):210-221.
  • Chafee MV, Crowe DA. Implicit and explicit learning mechanisms meet in monkey prefrontal cortex. Neuron. 2017;96(2):256-258.
  • Averbeck BB, Chafee MV. Using model systems to understand errant plasticity mechanisms in psychiatric disorders. Nat Neurosci. 2016;19:1418-1425.
  • Blackman RK, Crowe DA, DeNicola AL, Sakellaridi S, MacDonald AW 3rd, Chafee MV. Monkey prefrontal neurons reflect logical operations for cognitive control in a variant of the AX continuous performance task (AX-CPT). J Neurosci. 2016;36:4067-4079.
  • MacDonald Iii AW, Zick JL, Chafee MV, Netoff TI. Integrating insults: Using fault tree analysis to guide schizophrenia research across levels of analysis. Front Hum Neurosci. 2016 Jan 6;9:698.
  • Elshaikh AA, Sponheim SR, Chafee MV, MacDonald AW. Spatial attentional control is not impaired in schizophrenia: Dissociating specific deficits from generalized impairments. J Abnorm Psychol. 2015;124(2):302-308.
  • Crowe DA, Goodwin SJ, Blackman RK, Sakellaridi S, Sponheim SR, MacDonald AW 3rd, Chafee MV. Prefrontal neurons transmit signals to parietal neurons that reflect executive control of cognition. Nat Neurosci. 2013;16(10):1484-91.
  • Blackman RK, Macdonald AW 3rd, Chafee MV. Effects of ketamine on context-processing performance in monkeys: a new animal model of cognitive deficits in schizophrenia. Neuropsychopharmacology. 2013;38(11):2090-2100.
  • Chafee MV, Crowe DA. Thinking in spatial terms: decoupling spatial representation from sensorimotor control in monkey posterior parietal areas 7a and LIP. Front Integr Neurosci. 2013;6:112.
  • Chafee MV. A scalar neural code for categories in parietal cortex: representing cognitive variables as "more" or "less". Neuron. 2013;77(1):7-9.
  • Goodwin SJ, Blackman RK, Sakellaridi S, Chafee MV. Executive control over cognition: stronger and earlier rule-based modulation of spatial category signals in prefrontal cortex relative to parietal cortex. J Neurosci. 2012;32(10):3499-515.

Current Graduate Students:

Sam Brunson (Neuroscience, University of Minnesota).

Former Graduate Students:

Min-Yoon Park (Ph.D. 2020, Neuroscience, University of Minnesota).

Adele DeNicola  (Ph.D. 2019, Neuroscience, University of Minnesota).

Jennifer Zick (Ph.D. 2018, Neuroscience, University of Minnesota).

Rachael Blackman (Ph.D. 2013, Neuroscience, University of Minnesota).

Matthew Chafee