Michael Georgieff, M.D.

Professor, Department of Pediatrics, Division of Neonatology Co-Director, Center for Neurobehavioral Development

E-MAIL: georg001@umn.edu

Research Interests:

The Georgieff laboratory studies the effects of late fetal and early neonatal iron deficiency on the developing hippocampus and learning and memory behavior in humans and in rodent models. The lab is funded by a grant in its 15th year from NICHD to study this subject at multiple levels including human behavior, human neuroimaging with event related potentials (research in collaboration with Charles Nelson), rodent biochemistry using NMR spectroscopy at 9.4 Tesla, rodent electrophysiology (in collaboration with Michael O'Connor's lab), cell signaling, and rodent behavior (in collaboration with Jonathan Gewirtz). The laboratory has developed two genetic models that interupt iron uptake by the hippocampus at this critical point in development. The hypotheses are that iron deficiency in this developmental time period causes changes in hippocampal CA1 dendritic structure and function that accounts for abnormal recognition memory behavior in iron deficient humans and rodents.

Selected Publications:

(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

Cusick SE, Opoka RO, Abrams SA, John CC, Georgieff MK, Mupere E. Delaying Iron Therapy until 28 Days after Antimalarial Treatment Is Associated with Greater Iron Incorporation and Equivalent Hematologic Recovery after 56 Days in Children: A Randomized Controlled Trial. J Nutr. 2016 Jun 29;.

Georgieff MK, Brunette KE, Tran PV.  Early life nutrition and neural plasticity. Dev Psychopathol. 2015 May;27(2):411-23.

Tran PV, Kennedy BC, Pisansky MT, Won K-J, Gewirtz JC, Simmons RA, Georgieff MK. Prenatal choline supplementation diminishes early –life iron deficiency induced preprogramming of networks associated with behavioral abnormalities in the adult rat hippocampus. J Nutrition, 2015, in press.

Burns M, Muthupalani S, Ge Z, Wang TC, Cunningham C, Ennis K, Georgieff MK, Fox JG. Heliocobacter pylori infection induces anemia, depletes serum iron storage and alters iron-related and adult brain gene expression in male INS-GAS mice. PLoS One, 2015, in press.

Fuglestad AJ, Kroupina MG, Johnson DE, Georgieff MK. Micronutrient deficiencies and neurodevelopmental deficits in internationally adopted children. Acta Paediatrica, 2015, in press.

Monk C, Georgieff MK, Xu D, Hao X, Bansal R, Gustafsson H, Spicer J, Peterson BS. Maternal prenatal iron status and tissue organization in the neonatal brain. Pediatric Research, 2015, in press.

Wozniak JR, Fuglestad AJ, Eckerle JK, Fink BA, Hoecker CJ, Radke J, Kroupina MG, Miller NC, Brearley AM, Zeisel SH, Georgieff MK. Choline supplementation in children with Fetal Alcohol Spectrum Disorders (FASD) improves memory performance in 2-3 year olds: A randomized, double-blind, placebo-controlled trial. Am J Clin Nutr, 2015, in press.

Lonnerdal B, Georgieff MK, Hernell O. Developmental physiology of iron absorption, homeostasis and metabolism in the healthy term infant. J Pediatr, 2015, in press.

Hernell O, Fewtrell MS, Georgieff MK, Krebs NF, Lonnerdal B. Summary of current recommendations on iron provision and monitoring iron status for breastfed and formula-fed infants in resource-rich and resource-constrained countries. J Pediatr, 2015, in press.

Domellof M, Georgieff MK. Postdischarge iron requirements of the preterm infant. J Pediatr, 2015, in press.

Bastian TW, Santarriaga S, Nguyen TA, Prohaska JR, Georgieff MK, Anderson GW. Fetal and neonatal iron deficiency but not copper deficiency increases vascular complexity in the developing rat brain. Nutr Neurosci. Epub ahead of print, 2015. PMID 26177275.

Jabès A, Thomas KM, Langworthy S, Georgieff MK, Nelson CA. Functional and Anatomic Consequences of Diabetic Pregnancy on Memory in Ten-Year-Old Children.J Dev Behav Pediatr. 2015 Sep;36(7):529-35.

Zhao G, Xu G, Zhou M, Jiang Y, Richards B, Clark KM, Kaciroti N, Georgieff MK, Zhang Z, Tardif T, Li M, Lozoff B. Prenatal Iron Supplementation Reduces Maternal Anemia, Iron Deficiency, and Iron Deficiency Anemia in a Randomized Clinical Trial in Rural China, but Iron Deficiency Remains Widespread in Mothers and Neonates. J Nutr. 2015 Aug;145(8):1916-23.

Wallin DJ, Tkac I, Stucker S, Ennis KM, Sola-Visner M, Rao R, Georgieff MK. Phlebotomy-induced anemia alters hippocampal neurochemistry in neonatal mice. Pediatr Res. 2015 Jun;77(6):765-71.

Osterholm EA, Georgieff MK. Chronic inflammation and iron metabolism. J Pediatr. 2015 Jun;166(6):1351-7.e1.

Georgieff MK, Brunette KE, Tran PV. Early life nutrition and neural plasticity. Dev Psychopathol. 2015 May;27(2):411-23.

Tran, P. V., Kennedy, B. C., Lien, Y. C., Simmons, R. A., & Georgieff, M. K. Fetal iron deficiency induces chromatin remodeling at the Bdnf locus in adult rat hippocampus. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2015 Feb 15;308(4):R276-82.

Kroupina MG, Toeman L, Aidjanov MM, Georgieff MK, Hearst MO, Himes JH, Johnson DE, Miller BS, Syzdykova AM, Sharmanov TS. Predictors of developmental status in young children living in institutional care in Kazakhstan. Maternal and Child Health Journal, Epub ahead of print, in press, 2014. PMID 25480471

Turcotte LM, Georgieff MK, Ross JA, Feusner FH, Tomlinson GE, Malogolowkin MH, Krailo MD, Miller N, Fonstad R, Spector LG. Neonatal medical exposures and characeristics of low birth weight hepatoblastoma cases: A report from the Children's Oncology Group. Pediatr Blood Cancer, 61:2018-23; 2014. PMID25044669

Doom JR, Georgieff MK, Gunnar MR. Institutional Care and Iron Deficiency Increase ADHD Symptomology and Lower IQ 2.5-5 Years Post-adoption. Developmental Science, epub ahead of print, in press, 2014. NIHMS 620332.

Wachs TD, Georgieff M, Cusick S, McEwan B. Issues in the timing of integrated early interventions: contributions from nutrition, neuroscience and psychological research. Annals of the New York Academy of Sciences, 1308: 89-106, 2014. PMC4075015

Doom JR, Gunnar MR, Georgieff MK. Beyond Stimulus Deprivation: Iron Deficiency and Cognitive Deficits in Postinstitutionalized Children. Child Dev. 5:1805-12; 2014. PMID24597672

Bastian TW, Prohaska JR, Georgieff MK, Anderson GW. Fetal and neonatal iron deficiency exacerbates mild thyroid hormone insufficiency effects on male thyroid hormone levels and brain thyroid hormone-responsive gene expression. Endocrinology. 155(3): 1157-67; 2014. PMID24424046

Doom JR, Georgieff MK. Striking while the iron is hot: Understanding the biological and neurodevelopmental effects of iron deficiency to optimize intervention in early childhood. Curr Pediatr Rep. 2014 Dec 1;2(4):291-298.

Ramel SE, Brown LD, Georgieff MK. The Impact of Neonatal Illness on Nutritional Requirements-One Size Does Not Fit All. Curr Pediatr Rep. 2014 Dec;2(4):248-254.

Kennedy, B. C., Dimova, J. G., Siddappa, A. J., Tran, P. V., Gewirtz, J. C., & Georgieff, M. K. Prenatal Choline Supplementation Ameliorates the Long-Term Neurobehavioral Effects of Fetal-Neonatal Iron Deficiency in Rats. The Journal of nutrition, 2014 Nov;144(11), 1858-1865.

Fretham SJB, Carlson ES, Wobken J, Tran PV, Petryk A, Georgieff MK. Temporal manipulation of transferrin receptor-1 dependent iron uptake identifies a sensitive period in mouse hippocampal neurodevelopment. Hippocampus, epub Feb 26, NIHMS 348733, 2012. 

Georgieff MK. Long-term brain and behavioral consequences of early iron deficiency. Nutr Rev. 2011 Nov;69 Suppl 1:S43-8. doi: 10.1111/j.1753-4887.2011.00432.x.

Rao R, Tkac I, Schmidt AT, Georgieff MK. Fetal and neonatal iron deficiency causes volume loss and alters the neurochemical profile of the adult rat hippocampus. Nutr Neurosci. 2011 Mar;14(2):59-65.

Ramel SE, Gray HL, Ode KL, Younge N, Georgieff MK, Demerath EW. Body composition changes in preterm infants following hospital discharge: comparison with term infants. J Pediatr Gastroenterol Nutr. 2011 Sep;53(3):333-8.

Lehmann AE, Ennis K,Georgieff MK, Rao R, Tran PV. Evidence for a hyporesponsive limbic-hypothalamic-pituitary-adrenal axis following early-life repetitive hypoglycemia in adult male rats. Am J Physiol Regul Integr Comp Physiol. 2011 Aug;301(2):R484-90.

Fretham SJB, Carlson ES, Georgieff MK. The role of iron in learning and memory. Advances in Nutrition, 2: 1-10, 2011.

Schmidt AT, Ladwig EK, Wobken JD, Grove WM, Georgieff MK. Delayed alternation performance in rats following recovery from early iron deficiency. Physiol Behav. 2010 Nov 2;101(4):503-8.

Tran PV, Georgieff MK, Engeland WC. Sodium depletion increases sympathetic neurite outgrowth and expression of a novel TMEM35 gene-derived protein (TUF1) in the rat adrenal zona glomerulosa. Endocrinology. 2010 Oct;151(10):4852-60.

Brunette KE, Tran PV, Wobken JD, Carlson ES, Georgieff MK . Gestational and Neonatal Iron Deficiency Alters Apical Dendrite Structure of CA1 Pyramidal Neurons in Adult Rat Hippocampus. Dev Neurosci. 2010 Aug;32(3):238-48.

Carlson ES, Fretham SJ, Unger EL, O'Connor MB, Petryk A, Schallert T, Rao R, Tkac I, Georgieff MK. Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems. J Neurodev Disorders, in press, 2010.

Bastian TW, Prohaska JR, Georgieff MK , Anderson GW. Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone levels. Endocrinology, in press, 2010.

Schmidt AT, Ladwig EK, Wobken JD, Grove WM, Georgieff MK . Delayed alternation performance in rats following recovery from early iron deficiency. Physiology and Behavior, in press, 2010

Carlson ES, Tkac I, Magid R, O'Connor MB, Andrews NC, Schallert T, Gunshin H, Georgieff MK , Petryk A. Iron is essential for neuron development and memory function in mouse hippocampus.  J Nutrition, Apr;139(4):672-9, 2009.

Riggins T, Miller NC, Bauer PB, Georgieff MK , Nelson CA. Consequences of Low Neonatal Iron Status due to Maternal Diabetes Mellitus on Explicit Memory Performance in Childhood. Developmental Neuropsychology,  34:762-79, 2009.

Current Graduate Students:

Diana Wallin (Neuroscience, University of Minnesota)

Amanda Barks (Neuroscience, University of Minnesota).

Former Graduate Students:

Bruce Kennedy (Ph.D. 2016, Neuroscience, University of Minnesota).

Liam Callahan (Ph.D. 2015, Neuroscience, University of Minnesota).

Stephanie Fretham (Ph.D. 2010, Neuroscience, University of Minnesota).

Katya Brunette (Ph.D. 2009, Neuroscience, University of Minnesota).

Erik Carlson (Ph.D. 2008, Neuroscience, University of Minnesota).

Lyric Jorgenson (Ph.D. 2005, Neuroscience, University of Minnesota).