My professional goal is the exploration, refinement and invention of methodological tools that provide quantitative measures of tissue metabolism, structure, and function in vivo. I mainly focus on developing methods that will advance our understanding of the brain and have used these methods to identify the impact of diseases on cerebral metabolism, structure, and function in humans.
My studies of functional magnetic resonance spectroscopy (fMRS) at ultra-high magnetic have allowed, for the first time, the detection of changes in concentration of metabolites with exceptional sensitivity and reliability in the activated human cortex . fMRS has a profound impact on the understanding of the metabolic interactions involved in neuronal activity and can shed new light into the mechanisms of the chemical interactions necessary to support the energy demand involved in neuronal processing. Currently my lab is using fMRS to measure neurochemical concentrations during functional paradigms that increase neuronal inhibition processes. The results of this research will be critical for our basic understanding of overall brain function and for understanding and monitoring brain disorders for which inhibition processes are compromised, such as Parkinson’s disease, epilepsy, schizophrenia, etc. We are also beginning new fMRS experiments during altered physiological conditions such as hypoxia, in conditions of substance abuse such as chronic smoking, and after neuromodulation intervention with Transcranial Magnetic Stimulation (TMS).
Finally, I have extensive interests and expertise also in other magnetic resonance imaging (MRI) methodologies such as perfusion-MRI with arterial spin labeling (ASL), and blood-oxygenation-level-dependent (BOLD) functional MRI. By making use of these methodologies, we are currently examining the impact of diabetes and recurrent iatrogenic hypoglycemia on brain function; additionally, we aim at establishing whether the neurovascular coupling in diabetes is impaired. Finally, focused on innovation and translational research, we are developing and utilizing a variety of novel MR methods based on rotating frame relaxations and magnetization transfer to identify pathological and neurodegenerative processes in brain diseases like multiple sclerosis and Parkinson’s disease.
(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
Nissi MJ, Salo E-N, Tiitu V, Liimatainen T, Michaeli S, Mangia S, Ellermann J, Nieminen MT. Multi-Parametric MRI characterization of enzymatically degraded articular cartilage. Journal of Orthopaedic Research.
Moheet A, Mangia S, Kumar A, Tesfaye N, Eberly LE, Bai Y, Kubisiak K, Seaquist ER. Naltrexone for treatment of impaired awareness of hypoglycemia in type 1 diabetes: A randomized clinical trial. J Diabetes Complications. 2015 Aug 12.
Moheet A, Mangia S, Seaquist ER. Impact of diabetes on cognitive function and brain structure. Ann N Y Acad Sci. 2015 Jul 1.
Bednařík P, Tkáč I, Giove F, DiNuzzo M, Deelchand DK, Emir UE, Eberly LE, Mangia S Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla. J Cereb Blood Flow Metab. 2015 Mar 31;35(4):601-10.
Hakkarainen H, Sierra A, Mangia S, Garwood M, Michaeli S, Gröhn O, Liimatainen T MRI Relaxation in the Presence of Fictitious Fields Correlate with Myelin Content in Normal Rat Brain. Magnetic Resonance in Medicine. 2015; Feb 3.
Satzer D, DiBartolomeo C, Ritchie MM, Storino C, Liimatainen T, Hakkarainen H, Idiyatullin D, Mangia S, Michaeli S, Parr AM, Low WC. Assessment of dysmyelination with RAFFn MRI: application to murine MPS I. PLoS One. 2015 Feb 13;10(2):e0116788.
DiNuzzo M, Giove F, Maraviglia B, Mangia S Monoaminergic control of cellular glucose utilization by glycogenolysis in neocortex and hippocampus. Neurochemical Research. 2015; 40:2493–504.
Sorce DJ, Mangia S, Liimatainen T, Garwood M, Michaeli S. Exchange-induced relaxation in the presence of a fictitious field. J Magn Reson. 2014 Aug;245:12-6.
DiNuzzo M, Mangia S, Maraviglia B, Giove F. Physiological bases of the K+ and the glutamate/GABA hypotheses of epilepsy. Epilepsy Res. 2014 Aug;108(6):995-1012.
Tuite PJ, Mangia S, Michaeli S. Magnetic Resonance Imaging (MRI) in Parkinson's Disease. J Alzheimers Dis Parkinsonism. 2013 Mar 25;Suppl 1:001.
Mangia S, Carpenter A, Tyan A, Eberly LE, Garwood M, Michaeli S. Magnetization transfer and adiabatic T1ρ reveal abnormalities in normal appearing white matter of subjects with multiple sclerosis. Multiple Sclerosis Journal. 2013; 20:1066–1073.
Mangia S, Kumar AF, Moheet AA, Roberts R, Eberly LE, Seaquist ER, Tkac I. Neurochemical profile of patients with type 1 diabetes measured by 1H-MRS at 4T. Journal of Cerebral Blood Flow and Metabolism. 2013; 33:754–759.
Mangia S, Tesfaye N, De Martino F, Kumar AF, Kollasch P, Moheet AA, Eberly LE, Seaquist ER. Hypoglycemia-induced increases in thalamic cerebral blood flow are blunted in subjects with type 1 diabetes and hypoglycemia unawareness. Journal of Cerebral Blood Flow and Metabolism. 2012; 32:2084–2090.
Mangia S, Liimatainen T, Garwood M, Tkac I, Henry P-G, Deelchand D, Michaeli S. Frequency offset dependence of adiabatic rotating frame relaxation rate constants: relevance to MRS investigations of metabolite dynamics in vivo. NMR in Biomedicine. 2011; 24:807–814.
Mangia S, Giove F, Tkac I, Logothetis NK, Henry P-G, Olman CA, Maraviglia B, Di Salle F, Ugurbil K. Metabolic and hemodynamic events following changes in neuronal activity: current hypotheses, theoretical predictions and in vivo NMR experimental findings. Journal of Cerebral Blood Flow and Metabolism. 2009; 29:441–463.
Mangia S, Tkac I, Gruetter R, Van De Moortele P-F, Maraviglia B, Ugurbil K. Sustained neuronal activation raises oxidative metabolism to a new steady state level: evidence from 1H NMR spectroscopy in the human visual cortex. Journal of Cerebral Blood Flow and Metabolism. 2007; 27:1055–1063.