Undergraduate Institution and Major:
Esther Krook-Magnuson, Ph.D, Department of Neuroscience
Thesis Committee Members:
- David Redish Ph.D., Department of Neuroscience (Chair)
- Esther Krook-Magnuson, PhD., Department of Neuroscience
- Timothy Ebner, MD, Ph.D., Department of Neuroscience
- Hubert Lim, Ph.D., Department of Biomedical Engineering
Description Of Graduate Research:
The cerebellum, a canonically sensorimotor structure, is being increasingly appreciated for its relationship to cognitive brain areas and tasks. In particular, cerebellar modulation has been shown to influence hippocampal functioning in an epileptic brain. This finding has prompted my exploration of that relationship in a healthy brain, addressing such questions as which hippocampal populations respond to cerebellar activity, how does cerebellar modulation alter hippocampal neuronal dynamics, and what are the behavioral consequences of this activity. I utilize transgenic mice, optogenetics, calcium imaging, immunoprocessing, and a variety of behavioral tests to answer these questions.
Graduate Level Publications:
- Zeidler Z, Brandt-Fontaine M, Leintz C, Krook-Magnuson C, Netoff T, Krook-Magnuson E.Targeting the mouse ventral hippocampus in the intrahippocampal kainic acid model of temporal lobe epilepsy. eNeuro. 2018 Aug 8;5(4). pii: ENEURO.0158-18.2018.
- Zeidler Z, Krook-Magnuson E. Back to the dentate: Network changes of early- and late-born dentate granule cells. Epilepsy Curr. 2018 Jan-Feb;18(1):49-50.
- Zeidler Z, Krook-Magnuson E. One site to rule them all: Toward a master regulator of ictal activity. Epilepsy Curr. 2016;16:170–171.
- Qin M, Zeidler Z, Moulton K, Krych L, Xia Z, Smith CB. Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome. Behav Brain Res. 2015;291:164–171.
- Qin M, Huang T, Krych L, Xia Z, Burlin T, Zeidler Z, Zhao T, Smith CB. R-baclofen reverses a social behavior deficit and elevated protein synthesis in a mouse model of fragile X syndrome. Inter J Neuropsychopharmacol. 2015;18(9). pii: pyv034. doi: 10.1093/ijnp/pyv034.
Graduate Level Abstracts:
- Zeidler Z, Brandt-Fontaine M, Leintz C, Allen CS, Netoff T, Krook-Magnuson E. Effects of Hippocampal subfield targeting on epileptic pathology in the IHKA mouse model. International Conference for Technology and Analysis of Seizures, Minneapolis, MN. 2017
- Zeidler Z, Hoffman K, Krook-Magnuson E. The Hippo-Bellum: Effects of cerebellar modulation on hippocampal activity. Gordon Research Conference on Novel Perspectives on Cerebellar Development, Physiology, and Disease, Lewiston, Maine. 2017
- Behavioral & Cognitive Neuroscience
- Neurodegenerative Diseases & Neural Injury
Graduate Level Awards And Honors:
- IEM Walter Barnes Lang Fellowship, 2017
- Morris Smithberg Memorial Prize Winner, 2015
- NSF IGERT Systems Neuroengineering Fellow, 2014
- Sylvain Lesne, Ph.D, Department of Neuroscience
- Walter Low, Ph.D, Department of Neurosurgery
- Stanley Thayer, Ph.D, Department of Pharmacology
- Esther Krook-Magnuson, Ph.D, Department of Neuroscience
- Student Board Second Year Representative, 2015-2016
- Recruitment Weekend Retreat Committee, 2015-2016
- Brain Awareness Week, Minneapolis, MN (2015)
- Minnesota Science Museum: Science of Zombies, St. Paul, MN (2015)
- Minnesota Science Museum: Eye Candy, St. Paul, MN (2016)
- State Fair Neuroscience Booth, Falcon Heights, MN (2017)
Advanced Professional Degree Consulting Club, Minneapolis, MN (2016)
Society for Neuroscience (2012 – current)
Why Did You Choose MN?
Choosing which graduate school to attend is a complex decision. I chose to attend the University of Minnesota for my PhD in neuroscience because they had the greatest number of faculty with whom I wanted to work, rigorous coursework that looked actually relevant and interesting, and a supportive, fun group of graduate students that fostered the best atmosphere.
What Advice Would You Give a First Year Graduate Student?
Take an active role in your classes, research, and professional development.