Pierre-Gilles Henry , PhD

Associate Professor, Department of Radiology

E-MAIL: [email protected]

Research Interests:

My group focuses on using Magnetic Resonance Spectroscopy (MRS) to understand brain function at the biochemical and cellular level, and to identify new biomarkers of brain disorders. Current research topics include:
1. Understanding how neurons and astrocytes cooperate metabolically to support neurotransmission. For this purpose, we perform tracer studies using 13C-labeled substrates and 13C MRS, which allows us to measure metabolic rates non-invasively in the brain in both neurons and astrocytes.
2. Developing new metabolic models to analyze 13C MRS data, particularly two-compartment neuronal-glial models to measure the "glutamate-glutamine cycle". This would provide a non-invasive measurement of glutamatergic neurotransmission.
3. Exploring the potential of hyperpolarized 13C for the study of brain metabolism and for the detection of tumors in brain and other tissues.
4. Developing new methodologies for 1H MRS and 1H MRSI at very high-field for the measurement of metabolite concentrations ("neurochemical profile") with improved spatial and temporal resolution.

Publications:

  • Henry PG. Magnetic resonance spectroscopy and 13C metabolic modeling right under your nose! NMR biomed. 2024;37(6):5156.

  • Adanyeguh IM, Henry PG, Deelchand DK. Prospective motion correction for cervical spinal cord MRS. Magn Reson Med. 2024;91(1):19-27.

  • Adanyeguh IM, Joers JM, Deelchand DK, Hutter DH, Eberly LE, Guo B, Iltis I, Bushara KO, Henry PG, Lenglet C. Brain MRI detects early-stage alterations and disease progression in Friedreich ataxia. Brain Commun. 2023;5(4):fcad196.

  • Joers JM, Adanyeguh IM, Deelchand DK, Hutter DH, Eberly LE, Iltis I, Bushara KO, Lenglet C, Henry PG. Spinal cord magnetic resonance imaging and spectroscopy detect early-stage alterations and disease progression in Friedreich ataxia. Brain Commun. 2022;4(5):fcac246.

  • Georgiou-Karistianis N, Corben LA, Reetz K, Adanyeguh IM, Corti M, Deelchand DK, Delatycki MB, Dogan I, Evans R, Farmer J, França MC, Gaetz W, Harding IH, Harris KS, Hersch S, Joules R, Joers JJ, Krishnan ML, Lax M, Lock EF, Lynch D, Mareci T, Muthuhetti Gamage S, Pandolfo M, Papoutsi M, Rezende TJR, Roberts TPL, Rosenberg JT, Romanzetti S, Schulz JB, Schilling T, Schwarz AJ, Subramony S, Yao B, Zicha S, Lenglet C, Henry PG. A natural history study to track brain and spinal cord changes in individuals with Friedreich's ataxia: TRACK-FA study protocol. PLoS One. 2022;17(11):e0269649.

 

 Pierre-Gilles Henry , PhD