Excitotoxic Loss of Post-Synaptic Sites is Distinct Temporally and Mechanistically from Neuronal Death
Director of Research, ReShape Lifesciences Inc.
Director of Research, EnteroMedics
Undergraduate Institution and Major/Degree:
University of St. Thomas, BS Biochemistry and minor in Mathematics 2002
Stanley Thayer, Ph.D.
Graduate Research Description:
I am interested in studying synaptic changes that occur during excitotoxic-induced neuroegeneration. Excitotoxicity is caused by the excess release of glutamate and is thought to contribute to many neurodegenerative disorders including stroke, HIV associated dementia and Alzheimer's disease. I have developed a technique to track synaptic changes along with cell viability of single neurons over time. This has given us insights into the temporal relationship as well as mechanisms of synapse loss related to cell death.
Graduate Lab Rotations:
- David Redish
- Karen Ashe
- Stan Thayer
- Society for Neuroscience annual meeting - Fall 1999-2006
- Presented at Society for Neuroscience annual meeting 2000, 2005, 2006
- Waataja JJ, Tweden KS, Honda CN. Effects of high frequency alternating current on axonal conduction through the vagus nerve. J Neural Eng. 2011 Oct;8(5):056013.
- Kim HJ, Waataja JJ, Thayer SA. (Journal Cover) Cannabinoids inhibit network driven-synapse loss between hippocampal neurons in culture. J Pharmacol Exp Ther. 2008 325:850-858.
- Waataja JJ, Kim HJ, Roloff AM, Thayer SA. Excitotoxic loss of post-synaptic sites is distinct temporally and mechanistically from neuronal death. J Neurochem. 2008 104:364-375
- Gilbert GL, Kim HJ, Waataja JJ, Thayer SA. Delta9-tetrahydrocannabinol protects hippocampal neurons from excitotoxicity. Brain Res. 2007 1128:61-69.
- Song JH, Waataja JJ, Martemyanov KA. Subcellular targeting of RGS9-2 is controlled by multiple molecular determinants on its membrane anchor, R7BP. J Bio Chem.2006 281:15361-9.
Graduate Committee Members:
- Eric Newman
- Paul Letourneau
- Johnathan Merchant
- Society for Neuroscience
- Golden Valley, MN