Stanislav Kholmanskikh

Ph.D. 2002

Thesis Title:

Abnormalities of neuronal migration in mouse models of lissencephaly

Current Position:

Assistant Professor of Research, Neuroscience, Weill Cornell Medical College

Major Advisor(s):

  • Paul Letourneau
  • M. Elizabeth Ross

Selected Publications:

  • Mirzaa G, Parry DA, Fry AE, Giamanco KA, Schwartzentruber J, Vanstone M, Logan CV, Roberts N, Johnson CA, Singh S, Kholmanskikh SS, Adams C, Hodge RD, Hevner RF, Bonthron DT, Braun KPJ, Faivre L, Rivière JB, St-Onge J, Gripp KW, Mancini GM, Pang K, Sweeney E, van Esch H, Verbeek N, Wieczorek D, Steinraths M, Majewski J; FORGE Canada Consortium, Boycot KM, Pilz DT, Ross ME, Dobyns WB, Sheridan EG. De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. Nat Genet. 2014;46(5):510-515.
  • Gray JD, Kholmanskikh S, Castaldo BS, Hansler A, Chung H, Klotz B, Singh S, Brown AM, Ross ME. LRP6 exerts non-canonical effects on Wnt signaling during neural tube closure. Hum Mol Genet. 2013;22(21):4267-81.
  • Rivière JB, van Bon BW, Hoischen A, Kholmanskikh SS, O'Roak BJ, Gilissen C, Gijsen S, Sullivan CT, Christian SL, Abdul-Rahman OA, Atkin JF, Chassaing N, Drouin-Garraud V, Fry AE, Fryns JP, Gripp KW, Kempers M, Kleefstra T, Mancini GM, Nowaczyk MJ, van Ravenswaaij-Arts CM, Roscioli T, Marble M, Rosenfeld JA, Siu VM, de Vries BB, Shendure J, Verloes A, Veltman JA, Brunner HG, Ross ME, Pilz DT, Dobyns WB. Exome sequencing implicates de novo mutations in the actin genes ACTB and ACTG1 in Baraitser-Winter syndrome. Nature Genet. 2012;44:440-444.
  • Kholmanskikh SS, Koeller HB, Wynshaw-Boris A, Gomez T, Letourneau PC, Ross ME.Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility. Nature Neurosci. 2006;9:50-57
  • Kholmanskikh SS, Dobrin JS, Wynshaw-Boris A, Letourneau PC, Ross ME. Disregulated Rho GTPases and actin cytoskeleton contribute to the migration deficit in Lis1-deficient neurons. J Neurosci. 2003;23:8673-8681

Honors and Awards:

Stanislav Kholmanskikh