Glenn Lobo, PhD
Lab Website - https://med.umn.edu/ophthalmology/research/lobo-lab
My laboratory studies molecular mechanisms regulating dietary vitamin A transport to the eye and protein trafficking in photoreceptors, in the support of phototransduction and neural visual function. I apply state-of-the art structural biology, genomics, biochemical, and molecular biology technologies, including CRISPR-generated mutant zebrafish and knock-in mouse lines to determine the physiological consequences of low ocular vitamin A and protein mislocalization and its effects on vertebrate RPE, photoreceptor cell health and function, and neuro-auditory function.
Complete list of publications can be found on PubMed
- Adv Exp Med Biol. 2023;1415:499-505. In silico prediction of MYO1C-rhodopsin interactions and its significance in protein localization and visual function.
- Front Cell Dev Biol. 2023 Feb 22;11:1105657. Mapping of the extracellular RBP4 ligand binding domain on the RBPR2 receptor for Vitamin A transport.
- Nutrients. 2022 Jun 8;14(12):2371. Mice lacking the systemic vitamin A receptor RBPR2 show decreased ocular retinoids and loss of visual function.
- Ophthalmic Genet. 2022 Jun;43(3):285-300. The role of motor proteins in photoreceptor protein transport and visual function.
- Martin Ask N, Leung M, Radhakrishnan R, Lobo GP. Vitamin A transporters in visual function: A mini review on membrane receptors for dietary vitamin A uptake, atorage, and rransport to the eye. Nutrients. 2021 Nov 9;13(11):3987.
- Solanki AK, Biswal MR, Walterhouse S, Martin R, Kondkar AA, Knölker HJ, Rahman B, Arif E, Husain S, Montezuma SR, Nihalani D, Lobo GP. Loss of motor protein MYO1C causes rhodopsin mislocalization and results in impaired visual function. Cells. 2021 May 26;10(6):1322.
- Rohrer B, Biswal MR, Obert E, Dang Y, Su Y, Zuo X, Fogelgren B, Kondkar AA, Lobo GP, Lipschutz JH. Loss of the exocyst component Exoc5 in retinal pigment epithelium (RPE) results in RPE dysfunction, photoreceptor cell degeneration, and decreased visual function. Int J Mol Sci. 2021 May 11;22(10):5083.
- Lobo GP, Biswal MR, Kondkar AA. Molecular mechanisms of retinal cell degeneration and regeneration. Front Cell Dev Biol. 2021 Mar 5;9:667028.
- Lobo GP, Fulmer D, Guo L, Zuo X, Dang Y, Kim SH, Su Y, George K, Obert E, Fogelgren B, Nihalani D, Norris RA, Rohrer B, Lipschutz JH. The exocyst is required for photoreceptor ciliogenesis and retinal development. J Biol Chem. 2019 Apr 26;294(17):6710-6718.
- Shi Y, Obert E, Rahman B, Rohrer B, Lobo GP. The retinol binding protein receptor 2 (Rbpr2) is required for photoreceptor outer segment morphogenesis and visual function in zebrafish. Nature-Sci Rep. 2017 Nov 24;7(1):16207.