A. David Redish, Ph.D.

Distinguished McKnight University Professor, J.B. Johnston Land Grant Chair in Neuroscience, Department of Neuroscience

Research Interests:

Modern neuroscience sees the brain as an information-processing device. Understanding how the brain processes information requires understanding the representations used by the network of neurons that compose the brain. However, representations in the brain are distributed: each cell carries only a small portion of the total information. I am interested in questions of how neural structures work together to create systems able to accomplish behavioral tasks.

Our primary current projects are in the decision-making, neuroeconomics, and computational psychiatry.  Neurophysiologically, we are looking at how multiple learning and decision systems interact to produce behavior and how dysfunctions within those systems can drive problematic behaviors. We have extensive collaborations looking at how these systems are similar or different across species (mice, rats, humans), and the clinical implications of our understanding of these decision-making processes.

Lab Website: https://redishlab.umn.edu/

Selected Publications:

(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

  • Haynos AF, Widge AS, Anderson LM, Redish AD. Beyond Description and Deficits: How Computational Psychiatry Can Enhance an Understanding of Decision-Making in Anorexia Nervosa. Curr Psychiatry Rep. 2022 Jan;24(1):77-87. 
  • Redish AD, Kepecs A, Anderson LM, Calvin OL, Grissom NM, Haynos AF, Heilbronner SR, Herman AB, Jacob S, Ma S, Vilares I, Vinogradov S, Walters CJ, Widge AS, Zick JL, Zilverstand A. Computational validity: using computation to translate behaviours across species. Philos Trans R Soc Lond B Biol Sci. 2022 Feb 14;377(1844):20200525. 
  • Calvin OL, Redish AD. Global disruption in excitation-inhibition balance can cause localized network dysfunction and Schizophrenia-like context-integration deficits. PLoS Comput Biol. 2021 May 25;17(5):e1008985. 
  • Chen CS, Ebitz RB, Bindas SR, Redish AD, Hayden BY, Grissom NM. Divergent Strategies for Learning in Males and Females. Curr Biol. 2021 Jan 11;31(1):39-50.e4. 
  • Conelea CA, Jacob S, Redish AD, Ramsay IS. Considerations for Pairing Cognitive Behavioral Therapies and Non-invasive Brain Stimulation: Ignore at Your Own Risk. Front Psychiatry. 2021 Apr 12;12:660180. 
  • Cunningham PJ, Regier PS, Redish AD. Dorsolateral Striatal Task-initiation Bursts Represent Past Experiences More than Future Action Plans. J Neurosci. 2021 Sep 22;41(38):8051-8064. 
  • Duin AA, Aman L, Schmidt B, Redish AD. Certainty and uncertainty of the future changes planning and sunk costs. Behav Neurosci. 2021 Aug;135(4):469-486. 
  • Hunt LT, Daw ND, Kaanders P, MacIver MA, Mugan U, Procyk E, Redish AD, Russo E, Scholl J, Stachenfeld K, Wilson CRE, Kolling N. Formalizing planning and information search in naturalistic decision-making. Nat Neurosci. 2021 Aug;24(8):1051-1064.
  • Kalhan S, Redish AD, Hester R, Garrido MI. A salience misattribution model for addictive-like behaviors. Neurosci Biobehav Rev. 2021 Jun;125:466-477. 
  • Kazinka R, MacDonald AW 3rd, Redish AD. Sensitivity to Sunk Costs Depends on Attention to the Delay. Front Psychol. 2021 Feb 22;12:604843.
  • McLaughlin AE, Diehl GW, Redish AD. Potential roles of the rodent medial prefrontal cortex in conflict resolution between multiple decision-making systems. Int Rev Neurobiol. 2021;158:249-281. 
  • Schmidt B, Redish AD. Disrupting the medial prefrontal cortex with designer receptors exclusively activated by designer drug alters hippocampal sharp-wave ripples and their associated cognitive processes. Hippocampus. 2021 Oct;31(10):1051-1067. 
  • Hasz BM, Redish AD. Spatial encoding in dorsomedial prefrontal cortex and hippocampus is related during deliberation. Hippocampus. 2020 Nov;30(11):1194-1208.
  • Kummerfeld E, Ma S, Blackman RK, DeNicola AL, Redish AD, Vinogradov S, Crowe DA, Chafee MV. Cognitive control rrrors in nonhuman primates resembling those in schizophrenia reflect opposing effects of NMDA receptor blockade on causal interactions between cells and circuits in prefrontal and parietal cortices. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Apr 8. pii: S2451-9022(20)30078-1.
  • Hasz BM, Redish AD. Dorsomedial prefrontal cortex and hippocampus represent strategic context even while simultaneously changing representation throughout a task session. Neurobiol Learn Mem. 2020 Apr 7:107215. doi: 10.1016/j.nlm.2020.107215.
  • Walters CJ, Jubran J, Sheehan A, Erickson MT, Redish AD. Avoid-approach conflict behaviors differentially affected by anxiolytics: implications for a computational model of risky decision-making. Psychopharmacology (Berl). 2019 Mar 12. doi: 10.1007/s00213-019-05197-0.
  • Sweis BM, Thomas MJ, Redish AD. Beyond simple test of value: measuring addiction as a heterogeneous disease of computation-specific valuation processes. Learn. Mem. 2018;25:510-512.
  • McLoon LK, Redish AD. Demystifying graduate school: Navigating a PhD in neuroscience and beyond. J. Undergrad. Neurosci. Educ. 2018;16:A203-A209.
  • Sweis BM, Abram SV, Schmidt BJ, Seeland KD, MacDonald, AW III, Thomas MJ, Redish AD. Sensitivity to "sunk costs" in mice, rats, and humans. Science 2018;361:178-181.
  • Sweis BM, Redish AD, Thomas MJ. Prolonged abstinence from cocaine or morphine disrupts separable valuations during decision conflict. Nat Commun. 2018 Jun 28;9(1):2521.
  • Sweis BM, Thomas MJ, Redish AD. Mice learn to regret. PLoS Biol. 2018;16(6):e2005853.
  • Sweis BM, Larson EB, Redish AD, Thomas MJ. Altering gain of the infralimbic-to-accumbens shell circuit alters economically dissociable decision-making algorithms. Proc Natl Acad Sci U S A. 2018 Jun 18. pii: 201803084.
  • Amemiya S, Redish AD. Hippocampal theta-gamma coupling reflects state-dependent information processing in decision making. Cell Rep. 2018;22(12):3328-3338
  • Lisman J, Buzsáki G, Eichenbaum H, Nadel L, Ranganath C, Redish AD. Viewpoints: how the hippocampus contributes to memory, navigation and cognition. Nat Neurosci. 2017;20:1434-1447.
  • Friston KJ, Redish AD, Gordon JA. Computational Nosology and Precision Psychiatry. Comput Psychiatr. 2017;1:2-23. 
  • Papale AE, Zielinski MC, Frank LM, Jadhav SP, Redish AD. Interplay between hippocampal sharp-wave-ripple events and vicarious trial and error behaviors in decision making. Neuron. 2016;92(5):975-982.
  • Powell NJ, Redish AD. Representational changes of latent strategies in rat medial prefrontal cortex precede changes in behaviour. Nat Commun. 2016 Sep 22;7:12830.
  • Carter EC, Redish AD. Rats value time differently on equivalent foraging and delay-discounting tasks. J Exp Psychol Gen. 2016;145(9):1093-101.
  • Redish AD. Vicarious trial and error. Nat Rev Neurosci. 2016;17(3):147-59.
  • Amemiya S, Redish AD. Manipulating decisiveness in decision making: Effects of clonidine on hippocampal search strategies. J Neurosci. 2016;36(3):814-27.
  • Regier PS, Amemiya S, Redish AD. Hippocampus and subregions of the dorsal striatum respond differently to a behavioral strategy change on a spatial navigation task. J Neurophysiol. 2015;114(3):1399-416.
  • Stott JJ, Redish AD. Representations of value in the brain: An embarrassment of riches? PLoS Biol. 2015;13(6):e1002174.
  • Wikenheiser AM, Redish AD. Decoding the cognitive map: ensemble hippocampal sequences and decision making. Curr Opin Neurobiol. 2015;32:8-15.
  • Redish AD, Schultheiss NW, Carter EC. The computational complexity of valuation and motivational forces in decision-making processes. Curr Top Behav Neurosci. 2016;27:313-33.
  • Schultheiss NW, Redish AD. The compass within. Nat Neurosci. 2015;18(4):482-3.
  • Breton YA, Seeland KD, Redish AD. Aging impairs deliberation and behavioral flexibility in inter-temporal choice. Front Aging Neurosci. 2015 Mar 27;7:41.
  • Regier PS, Redish, AD. Contingency management and deliberative decision-making processes. Front Psychiatry. 2015 Jun 1;6:76.
  • Wikenheiser AM, Redish AD. Hippocampal sequences and the cognitive map. In: Analysis and Modeling of Coordinated Multi-neuronal Activity Springer New York, 2015; pp105-129.
  • Wikenheiser AM, Redish AD. Hippocampal theta sequences reflect current goals. Nat Neurosci. 2015;18(2):289-94.
  • Hills TT, Todd PM, Lazer D, Redish AD, Couzin ID; Cognitive Search Research Group. Exploration versus exploitation in space, mind, and society. Trends Cogn Sci. 2015;19(1):46-54.
  • Redish AD, Mizumori SJ. Memory and decision making. Neurobiol Learn Mem. 2015;117:1-3.
  • Powell NJ, Redish AD. Complex neural codes in rat prelimbic cortex are stable across days on a spatial decision task. Front Behav Neurosci. 2014 Apr 23;8:120.
  • Stott JJ, Redish AD. A functional difference in information processing between orbitofrontal cortex and ventral striatum during decision-making behaviour. Philos Trans R Soc Lond B Biol Sci. 2014;369(1655).
  • Wikenheiser AM, Redish AD. Decoding the cognitive map: ensemble hippocampal sequences and decision making. Curr Opin Neurobiol. 2014;32C:8-15.
  • Steiner AP, Redish AD. Behavioral and neurophysiological correlates of regret in rat decision-making on a neuroeconomic task. Nat Neurosci. 2014;17(7):995-1002.


  • Redish AD, Gordon JA. "Computational Psychiatry: New Perspectives on Mental Illness (MIT Press), 2016.

Current Graduate Students:

Cody Walters (Neuroscience, University of Minnesota).

Adrine Kocharian (Neuroscience, University of Minnesota)

Former Graduate Students:

Brendan Hasz (Ph.D. 2020, Neuroscience, University of Minnesota).

Brian Sweis (Ph.D. 2018, Neuroscience, University of Minnesota).

Andrew Papale (Ph.D. 2015, Neuroscience, University of Minnesota).

Paul Regier (Ph.D. 2015, Neuroscience, University of Minnesota).

Jeff Stott (Ph.D. 2015, Neuroscience, University of Minnesota).

Nate Powell (Ph.D. 2015, Neuroscience, University of Minnesota).

Andrew Wikenheiser (Ph.D. 2014, Neuroscience, University of Minnesota).

Adam Steiner (Ph.D. 2014, Neuroscience, University of Minnesota).

Adam Johnson (Ph.D. 2008, Neuroscience, University of Minnesota).

Jadin Jackson (Ph.D. 2006, Neuroscience, University of Minnesota).

Neil Schmitzer-Torbert (Ph.D. 2004, Neuroscience, University of Minnesota).

Picture of A. David Redish