AMPA Glutamate Receptor Trafficking in Models of Disease
Solutions Engineer II, SOVOS
Undergraduate Institution and Major/Degree:
B.A., Psychology and Political Science, 2008, Gustavus Adolphus College, MN
Dezhi Liao, M.D., Ph.D.
The role of functional and structural plasticity of dendritic spines in drug addiction has recently attracted great attention from both basic researchers and clinicians. Although it is known that drugs of abuse cause spine plasticity, the intracellular signaling pathway through which these changes are mediated is unknown. My thesis research aims to reveal a novel signaling pathway that mediates drug-induced plasticity of dendritic spines. Therefore, the CaMKII/Kalirin7/Rac1 signaling pathway may become a therapeutic target for the prevention and treatment of drug addiction.
- Mark Thomas
- Dezhi Liao
- Bob Meisel
- Society for Neuroscience - 2007, 2008, 2009, 2010 and 2012
- International Brain Research Meeting - 2011
- Bob Meisel - Chair
- Paulo Kofuji
- Stanley Thayer
- Dezhi Liao - Advisor
- Teravskis PJ, Covelo A, Miller EC, Singh B, Martell-Martínez HA, Benneyworth MA, Gallardo C, Oxnard BR, Araque A, Lee MK, Liao D. A53T mutant alpha-synuclein induces tau dependent postsynaptic impairment independent of neurodegenerative changes. J Neurosci. 2018;38:9754-9767.
- Liao D, Miller EC, Teravskis PJ. Tau acts as a mediator for Alzheimer's disease-related synaptic deficits. Eur J Neurosci. 2014;39(7):1202-13.
- Miller EC, Teravskis PJ, Dummer BW, Zhao X, Huganir RL, Liao D. Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer-induced AMPA glutamate receptor signaling deficits. Eur J Neurosci. 2014;39(7):1214-24.
- Miller EC, Zhang L, Dummer BW, Cariveau DR, Loh H, Law PY, Liao D. Differential modulation of drug-induced structural and functional plasticity of dendritic spines. Mol Pharmacol. 2012;82(2):333-43.
- Society for Neuroscience
- Racine, WI