Alyssa Soles

PhD 2024

PhD Thesis:

A neural basis for mutant ATAXIN-1 induced respiratory dysfunction in mouse models of spinocerebellar ataxia type 1.

Current Position

Postdoc University of Minnesota Twin Cities

Undergraduate Institution and Major:

Truman State University, B.S. in Biology, 2020

Graduate Advisor

Marija Cvetanovic, Ph.D., Department of Neuroscience
Harry Orr, Ph.D., Department of Laboratory Medicine and Pathology

Graduate Publications

  • Duvick L, Southern WM, Benzow KA, Burch ZN, Handler HP, Mitchell JS, Kuivinen H, Gadiparthi U, Yang P, Soles A, Sheeler CA, Rainwater O, Serres S, Lind EB, Nichols-Meade T, You Y, O'Callaghan B, Zoghbi HY, Cvetanovic M, Wheeler VC, Ervasti JM, Koob MD, Orr HT. Mapping SCA1 regional vulnerabilities reveals neural and skeletal muscle contributions to disease. JCI Insight. 2024 Mar 21;9(9):e176057.
  • Soles A, Selimovic A, Sbrocco K, Ghannoum F, Hamel K, Moncada EL, Gilliat S, Cvetanovic M. Extracellular matrix regulation in physiology and in brain disease. Int J Mol Sci. 2023 Apr 11;24(8):7049.
  • Handler HP, Duvick L, Mitchell JS, Cvetanovic M, Reighard M, Soles A, Mather KB, Rainwater O, Serres S, Nichols-Meade T, Coffin SL, You Y, Ruis BL, O'Callaghan B, Henzler C, Zoghbi HY, Orr HT. Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles. Neuron. 2023 Feb 15;111(4):493-507.
  • Rosa JG, Hamel K, Soles A, Sheeler C, Borgenheimer E, Gilliat S, Sbrocco K, Ghanoum F, Handler HP, Forster C, Rainwater O, Cvetanovic M. BDNF is altered in a brain-region specific manner and rescues deficits in Spinocerebellar Ataxia Type 1. Neurobiol Dis. 2023 Mar;178:106023.
  • Rosa JG, Hamel K, Sheeler C, Borgenheimer E, Gilliat S, Soles A, Ghannoum FJ, Sbrocco K, Handler HP, Rainwater O, Kang R, Cvetanovic M. Spatial and temporal diversity of astrocyte phenotypes in Spinocerebellar Ataxia Type 1 Mice. Cells. 2022 Oct 21;11(20):3323.

Awards and Honors

  • University of Minnesota Doctoral Dissertation Fellowship Nominee (2024)
  • Spring and Ying Ngoh Lin Award (2023)
  • National Ataxia Foundation Graduate Research Fellowship (2023
Soles