Kristina Fredriksen

Entering Class - 2019

E-MAIL:  [email protected]

PhD 2025

PhD Thesis

Targeting APOE4-related dysfunction and Alzheimer's disease pathology in human induced pluripotent stem cell (hiPSC)-derived models and in vivo.

Undergraduate Institution and Major:

University of Massachusetts - Amherst, B.S. in Translational Neuroscience and Music Cognition, 2016

Graduate Advisor:

Ling Li,  DVM, Ph.D., Department of Experimental and Clinical Pharmacology

Graduate Publications:

  • Singh A, Smedley GD, Rose JG, Fredriksen K, Zhang Y, Li L, Yuan SH. A high efficiency precision genome editing method with CRISPR in iPSCs. Sci Rep. 2024 Apr 30;14(1):9933.
  • Jeong A, Auger SA, Maity S, Fredriksen K, Zhong R, Li L, Distefano MD. In vivo prenylomic profiling in the brain of a transgenic mouse model of Alzheimer's disease reveals increased prenylation of a key set of proteins. ACS Chem Biol. 2022 Oct 21;17(10):2863-2876. Sci Rep. 2024 Apr 30;14(1):9933. 

Previous Publications:

  • Cuddy LK, Wani WY, Morella ML, Pitcairn C, Tsutsumi K, Fredriksen K, Justman CJ, Grammatopoulos TN, Belur NR, Zunke F, Subramanian A, Affaneh A, Lansbury PT Jr, Mazzulli JR. Stress-induced cellular clearance Is mediated by the SNARE protein ykt6 and disrupted by α-synuclein. Neuron. 2019;104(5):869-884.
  • Kim J, Hu C, Moufawad El Achkar C, Black LE, Douville J, Larson A, Pendergast MK, Goldkind SF, Lee EA, Kuniholm A, Soucy A, Vaze J, Belur NR, Fredriksen K, Stojkovska I, Tsytsykova A, Armant M, DiDonato RL, Choi J, Cornelissen L, Pereira LM, Augustine EF, Genetti CA, Dies K, Barton B, Williams L, Goodlett BD, Riley BL, Pasternak A, Berry ER, Pflock KA, Chu S, Reed C, Tyndall K, Agrawal PB, Beggs AH, Grant PE, Urion DK, Snyder RO, Waisbren SE, Poduri A, Park PJ, Patterson A, Biffi A, Mazzulli JR, Bodamer O, Berde CB, Yu TW. Patient-customized oligonucleotide therapy for a rare genetic disease. N Engl J Med. 2019;381(17):1644-1652.
  • Zunke F, Moise AC, Belur NR, Gelyana E, Stojkovska I, Dzaferbegovic H, Toker NJ, Jeon S, Fredriksen K, Mazzulli JR. Reversible conformational conversion of α-synuclein into toxic assemblies by glucosylceramide. Neuron. 2018;97(1):92-107.
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