Soluble alpha-synuclein oligomers are associated with reduced synapsin expression and enhanced cognitive decline in Alzheimer's disease
Now FIT-AD Project Manager, University of Minnesota
Undergraduate Institution and Major/Degree:
University of Minnesota, B. S., Electrical Engineering, 1982
Sylvain Lesne, Ph.D.
- Michael Lee
- Walter Low
- Sylvain Lesne
- Cheryl Olman
- Meeting of the Minds 2010, 2011, 2012
Selected Publications and Presentations:
- Yu F, Greimel S, Kelly K, Wyman JF. Strategies to engage older adults with behavioral and psychological symptoms of dementia in exercise: A multiple case study. Appl Nurs Res. 2017 Aug;36:77-80.
- Larson ME, Greimel SJ, Amar F, LaCroix M, Boyle G, Sherman MA, Schley H, Miel C, Schneider JA, Kayed R, Benfenati F, Lee MK, Bennett DA, Lesné SE. Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits. Proc Natl Acad Sci U S A. 2017;114(23):E4648-E4657. PMID: 28533388
- Larson ME, Sherman MA, Greimel S, Kuskowski M, Schneider JA, Bennett DA, Lesné SE. Soluble α-synuclein is a novel modulator of Alzheimer's disease pathophysiology. J Neurosci. 2012;32(30):10253-66.
- Richfield, MN