Brianna Dailey-Krempel

Entering Class - 2021

Pronouns: she/her

E-MAIL:  [email protected]

Undergraduate Institution and Major:

University of Nevada-Reno, B.S. in Neuroscience, 2020

Graduate Advisor

Lucy Vulchanova, Ph.D., Department of Neuroscience
John Osborn, Ph.D., Department of Surgery

Graduate Research:

My thesis research focuses on the role of renal afferent (sensory) nerves in the development and maintenance of a salt-induced model of hypertension. I use adeno-associated viruses to trace renal afferents within the renal cortex and renal pelvis to identify where these afferents terminate centrally in the spinal cord and caudal brainstem. Using the deoxycorticosterone-acetate (DOCA)-salt mouse model of hypertension, I am investigating which central autonomic blood pressure regulating regions are activated at two time points of hypertension development and maintenance, and using renal afferent denervation to see which regions may be modulated by renal afferent input.

Graduate Publications

  • Osborn JW and Dailey-Krempel B. Left out in the cold? The sympathetic signature of cold-induced hypertension. Hypertension. 2025 Jan. doi: 10.1161/hypertensionaha.125.24634.
  • Evans LC*, Dailey-Krempel B*, Dayton A, Ruiz Lauar M, Vulchanova L, Osborn JW. Renal interoception in health and disease. Autonomic Neuroscience: Basic and Clinical. 2024 July. doi: 10.1016/j.autneu.2024.103208. [*Co-first, these authors contributed equally.]
  • Dailey-Krempel B, Martin A, Jo H-N, Junge H, Chen Z. A tug-of-war between DCC and ROBO1 signaling during commissural axon guidance. Cell Reports. 2023 May. doi: 10.1016/j.celrep.2023.112455.

Graduate Presentations

  • Dailey-Krempel B, O’Brien L, Riedl M, Zhang Y, Gohl D, Osborn JW, Vulchanova L. Transcriptomic Analysis of Kidney-Innervating Spinal and Vagal Sensory Neurons. American Physiology Summit, Baltimore, MD, April 2025. (poster)
  • Dailey-Krempel B, O’Brien L, Riedl M, Zhang Y, Gohl D, Osborn JW, Vulchanova L. Transcriptomic Analysis of Kidney-Innervating Spinal and Vagal Sensory Neurons. Keystone Symposia – Interoception: Neural Sensing and Control of Organ Function, Seattle, WA, April 2025. (poster)
  • Dailey-Krempel B, Osborn JW, Vulchanova L. Investigating the Role of Renal Afferent Nerves in Hypertension. Graduate Program in Neuroscience Annual Retreat Nano-Symposium, February 2025. (poster)
  • Dailey-Krempel B. Renal Afferent Nerves in Neurogenic Hypertension. Graduate Program in Neuroscience Colloquium Series, December 2024. (talk) Dailey-Krempel B. What is the Kidney Telling the Brain? Midbrains: Midwest Regional Undergraduate Research Symposium in Neuroscience Annual Conference, University of Wisconsin-Green Bay, Green Bay, WI, October 2024. (talk)
  • Dailey-Krempel B, Baumann D, Vulchanova L, Osborn JW. Analysis of Brain Regions Activated by Afferent Renal Nerves in DOCA-Salt Hypertensive Mice. American Physiology Summit, Long Beach, CA, April 2024. doi: 10.1152/physiol.2024.39.S1.1246. (poster)
  • Dailey-Krempel B, Baumann D, Osborn JW, Vulchanova L. Renal Afferent Input to Central Autonomic Blood Pressure Centers. Graduate Program in Neuroscience Annual Retreat Nano-Symposium, February 2024. (poster)
  • Dailey-Krempel B. Renal Afferent Input to Central Autonomic Blood Pressure Centers. Graduate Program in Neuroscience Colloquium Series, November 2023. (talk)
  • Dailey-Krempel B, Baumann D, Tyshynsky R, Ruiz Lauar M, Riedl M, Van Helden D, Evans L, Osborn JW, Vulchanova L. The Role of Afferent Renal Nerves in Hypertension: An Anatomical Approach. Graduate Program in Neuroscience Annual Retreat Nano-Symposium, March 2023. (poster)

Graduate Awards/Honors

  • 2024-present NIH NIDDK F31 Predoctoral Individual NRSA (1F31DK139599)
  • 2024 Sping and Ying Ngoh Lin Award – Research Independence
  • 2023, 2024 Sping and Ying Ngoh Lin Award – Full Length Paper
  • 2021-2022 NIH NINDS T32 Grant Appointee

GPN Committees

GPN Admissions Committee, 2023-present
GPN Student Board, 2023-present

Thesis Committee

Catherine Kotz, Ph.D., Departments of Geriatric Research, Education and Clinical Care (GRECC); Food Science and Nutrition; MN Obesity Center (Chair)
Lucy Vulchavnova, Ph.D., Department of Neuroscience (Co-Advisor)
John Osborn, Ph.D., Department of Surgery (Co-Advisor) 
Louise Evans, Ph.D., Department of Surgery 
Zhe Chen, Ph.D., Department of Neuroscience

Rotations

Alfonso Araque, Ph.D. & Paulo Kofuji, Ph.D., Department of Neuroscience
Zhe Chen, Ph.D., Department of Neuroscience
Lucy Vulchanova, Ph.D., Department of Neuroscience & John Osborn, Ph.D., Department of Surgery
Catherine Kotz, Ph.D., Departments of Geriatric Research, Education and Clinical Care (GRECC); Food Science and Nutrition; MN Obesity Center

Undergraduate Research

During undergrad, I was involved in a project investigating the role of GABA and insulin receptors in olfactory sensory neurons in the feeding behavior of Drosophila larvae.

Undergraduate Publications

  • Slankster E, Kollala S, Baria D, Dailey-Krempel B, Jain R, Odell S, and Mathew D. Mechanism underlying starvation-dependent modulation of olfactory behavior in Drosophila larva. Scientific Reports. 2020 Feb. 10:3119. doi: 10.1038/s41598-020-60098-z.

Undergraduate Awards/Honors

Nevada Undergraduate Research Award 2020

Dailey-Krempel