Network Consistency and Hippocampal Dynamics
Principal Data Scientist, Boston Scientific
Senior Data Strategy Consultant, Cerner/Clarus Group
Senior Manager of Neuroscience and Data Science, Medtronic.
Undergraduate Institution and Major/Degree:
- Oregon State University, BS, Physics, 2000
- Oregon State University, BS, Engineering Physics, 2000
A. David Redish, Ph.D.
Neural representations are distributed. This means, information about sensory, motor, or cognitive variables is spread across a population of neurons. To get at the dynamics of information processing in the brain then requires an understanding of the neural code not only at the single cell level, but also at the population level. While a specific variable or distribution may be reflected by a population code, measures are needed that reflect the quality of such a distributed representation. My graduate work has focused on this problem through two avenues of research.
Using attractor network models, I have developed and characterized two measures of representational quality. One, coherency, uses the known response properties of individual neurons to compare the current activity pattern within an ensemble with the expected activity pattern. The result is a statistical measure of representational quality that can detect dynamic anomalies in a population’s representational state. Another measure, ensemble consistency, has the advantage that it requires no explicit assumptions regarding the tuning of neurons in the ensemble making it ideal for exploring the dynamics of deep brain structures where neuronal response parameters are controversial or unknown. With these measures, I am looking at the temporal dynamics of the hippocampal representation while rats perform tasks of increasing spatial and cognitive complexity. I am examining single cell fluctuations and ensemble (~100 simultaneously recorded neurons) modulation to clarify the role of the hippocampus in spatial and temporal processing. Finally, I am interested in exploring statistical paradigms for evaluating population activity and its relation to learning.
- Martha Flanders
- Dan Kersten
- A. David Redish
- Bagrat Amirikian
Courses Taken Beyond the Core Courses:
- BIOC 3021 Biochemistry
- BIOL 4004 Cell Biology
- NSC 8217 Syst comp neurosci
- BIOL 4003 Genetics
- NSC 5201 Comp Neurosci I
- NSC 5202 Comp Neurosci II
- MATH 5535 Dynamical Systems and Chaos
- MATH 5651 Prob-Stat Theory
- GRAD 8101 Teaching in Higher Education
Graduate Level Minor:
- Supporting Program
- Jackson JC*, Lansink C.*, Lankelma J, Ito R, Robbins TW, Everitt B, Pennartz CMA. Reward cues in space: commonalities and differences in neural coding by hippocampal and ventral striatal ensembles. J Neurosci. 2012;32:12444-12459.
- Ferguson JE, Boldt C, Puhl JG, Stigen TW, Jackson JC, Crisp KM, Mesce KA, Netoff TI, Redish AD. Nanowires precisely grown on the ends of microwire electrodes permit the recording of intracellular action potentials within deeper neural structures. Nanomedicine 2012;7(6):847-854.
- Ferguson JE, Jackson JC, Redish AD. An inside look at hippocampal silent cells. Neuron 2011;70:3-5.
- Sanchez-Fibla M, Bernardet U, Wasserman E, Pelc T, Mintz M, Jackson JC, Lansink C, Pennartz C, Paul F.M.J. Verschure PRMJ. Allostatic control for robot behavior regulation: A comparison study with rodent behavior. Advances in Complex Systems. 2010;13 (3):377-403
- Jackson JC, Redish AD. Network dynamics of hippocampal cell assemblies resemble multiple spatial maps within single tasks. Hippocampus 2007;17(12)1209-1229.
- Jackson JC, Johnson A, Redish AD. Hippocampal sharp waves and reactivation during awake states depend on repeated sequential experience. J Neurosci. 2006;26:12415-12426.
- Schmitzer-Torbert NC, Jackson JC, Henze D, Harris K, Redish AD. Quantitative measures of cluster quality for use in extracellular recordings. Neuroscience 2005;131:1-11
- Jackson JC, Redish AD. Measuring ensemble consistency without measuring tuning curves. Neurocomputing, 2004;58-60C: 91-99
- Jackson JC, A.D. Redish AD. Detecting dynamical changes within a simulated neural ensemble using a measure of representational quality. Network. 2003;14(4):629-45.
Conferences Attended and Presentations:
- Masimore B, Schmitzer-Torbert NC, Jackson JC, Kakalios J, AD Redish AD. Synchronous oscillations in striatal local field potentials correlate with movement initiation. Society for Neuroscience Abstracts 30, 2004.
- Jackson JC, Schmitzer-Torbert NC, Harris KD, Redish AD. Changes in patterns of neural firing in the rodent dorsal striatum precede development of a regular route. Society for Neuroscience Abstracts 29, 2003.
- Jackson JC, Redish AD. Quantitative assessment of extracellular multichannel recording quality using measures of cluster separation. Society for Neuroscience Abstracts 29, 2003
- Redish AD, Schmitzer-Torbert NC, Jackson JC. Measuring the consistency .of a neuronal representation. Computational Neuroscience Meeting, 2002.
- Redish AD, Schmitzer-Torbert NC, Jackson JC. Classification of dorsal striatal neurons from extracellular recordings in awake behaving rats. Society for Neuroscience Abstracts 28, 2002.
- Schmitzer-Torbert NC, Jackson JC, Redish AD. Behavioral correlates of neuronal activity in the rodent dorsal striatum: The Multiple-T task. Society for Neuroscience Abstracts 28, 2002.
- Jackson JC, Schmitzer-Torbert NC, Redish AD. Behavioral correlates of neuronal ensemble in dorsal striatum on a conditioned response task. Society for Neuroscience Abstracts 28m, 2001.
- Jackson JC, Hondzinski JM, Soechting JF, Flanders M. Kinematic Adaptation To Altered Arm Properties, Neural Control of Movement conference, Seville, Spain; 2001.
- A. David Redish - Advisor
- Richard E. Poppele - Chair
- John F. Soechting
- James Kakalios
Awards and Honors:
- 2000-2003, NSF-IGERT Computational Neuroscience Fellowship (University of Minnesota)
- 2000, Phi Kappa Phi, National Honors Society (Oregon State
- 2000, Golden Key, National Honors Society (Oregon State
- 1999-2000, Gleason Scholarship (Oregon State University)
- 1997-1998, Phi Theta Kappa, National Honors Society (Linn-Benton
- 1997-1998, National Deans List (Phi Theta Kappa, Linn-Benton Community College)
- 1998, Rasmussen Scholarship (Linn-Benton Community College)
- 1996-1997, Linn-Benton Community College Grant
- Institute for Eletrical and Electronic Engineers (IEEE; 1997 - present) Student member.
- Society for Neuroscience (2001-present) Student member.
- Systems Man and Cybernetics Society (IEEE; 1997 - present) Student member.
- Helena, Montana