Esther Krook-Magnuson, Ph.D.

Associate Professor, Department of Neuroscience

E-MAIL: [email protected]


Advising Statement:

Research Interests:

Neuronal networks, diversity, and specificity of function are important to both physiological processes and neurological disorders, including epilepsy.  My laboratory seeks to improve our understanding of how cells interact within a network, how networks interact with each other, and the physiological roles of neuronal populations.  In this regard, key questions remain in epilepsy research, including what are the principal networks, conditions, and cell types involved in initiating, sustaining, propagating, terminating, and potentially suppressing, seizures.  By improving our understanding of these, we improve the prospects of someday reaching the goal of no seizures, no side effects, for all epilepsy patients.  My lab uses rodent models of neurological disorders, including temporal lobe epilepsy, and techniques including electrophysiology, optogenetics, immunocytochemistry, transgenic animals, and behavioral experiments to address these fundamental questions.

Selected Publications:

(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

  • Streng ML, Froula JM, Krook-Magnuson E. The cerebellum's understated role and influences in the epilepsies. Neurobiol Dis. 2023 May 18:106160.
  • Liu M, Liu H, Feng F, Krook-Magnuson E, Dudley SC. TRPM7 kinase mediates hypomagnesemia-induced seizure-related death. Sci Rep. 2023 May 15;13(1):7855.
  • Froula JM, Hastings SD, Krook-Magnuson E. The little brain and the seahorse: Cerebellar-hippocampal interactions. Front Syst Neurosci. 2023 Mar 23;17:1158492.
  • Stieve BJ, Smith MM, Krook-Magnuson E. LINCs are vulnerable to epileptic insult and fail to provide seizure control via on-demand activation. eNeuro. 2023 Jan 30:ENEURO.0195-22.2022.
  • Stieve BJ, Richner TJ, Krook-Magnuson C, Netoff TI, Krook-Magnuson E. Optimization of closed-loop electrical stimulation enables robust cerebellar-directed seizure control. Brain. 2023 Jan 5;146(1):91-108.
  • Streng ML, Tetzlaff M, Krook-Magnuson E. Distinct fastigial output channels and their impact on temporal lobe seizures. J Neurosci. 2021 Dec 8;41(49):10091-10107.
  • Yu K, Niu X, Krook-Magnuson E, He B. Intrinsic functional neuron-type selectivity of transcranial focused ultrasound neuromodulation. Nat Commun. 2021 May 4;12(1):2519.
  • Denison T, Koubeissi M, Krook-Magnuson E, Mogul D, Worrell G, Schevon C. Stimulating solutions for intractable epilepsy. Epilepsy Curr. 2021 Apr 30:15357597211012466.
  • Streng ML, Krook-Magnuson E.  The cerebellum and epilepsy. Epilepsy Behav. 2021 Aug;121(Pt B):106909.
  • Chen R, Gore F, Nguyen QA, Ramakrishnan C, Patel S, Kim SH, Raffiee M, Kim YS, Hsueh B, Krook-Magnusson E, Soltesz I, Deisseroth K. Deep brain optogenetics without intracranial surgery. Nat Biotechnol. 2021 Feb;39(2):161-164.
  • Billwiller F, Castillo L, Elseedy H, Ivanov AI, Scapula J, Ghestem A, Carponcy J, Libourel PA, Bras H, Abdelmeguid NE, Krook-Magnuson E, Soltesz I, Bernard C, Luppi PH, Esclapez M. GABA-glutamate supramammillary neurons control theta and gamma oscillations in the dentate gyrus during paradoxical (REM) sleep. Brain Struct Funct. 2020 Dec;225(9):2643-2668.
  • Nietz A, Krook-Magnuson C, Gutierrez H, Klein J, Sauve C, Hoff I, Christenson Wick Z, Krook-Magnuson E. Selective loss of the GABAAα1 subunit from Purkinje cells is sufficient to induce a tremor phenotype. J Neurophysiol. 2020 Oct 1;124(4):1183-1197.
  • Zeidler Z, Hoffmann K, Krook-Magnuson E. HippoBellum: acute cerebellar modulation alters hippocampal dynamics and function. J Neurosci. 2020:40(36):6910-6926.
  • Streng ML, Krook-Magnuson E. The cerebellum and epilepsy. Epilepsy Behav. 2020 Feb 5:106909.
  • Krook-Magnuson E. From point A to point B, and what it means for epilepsy. Epilepsy Curr. 2019 Dec 3:1535759719889626.
  • Streng ML, Krook-Magnuson E. Excitation, but not inhibition of the fastigial nucleus provides powerful control over temporal lobe seizures. J Physiol. 2020;598(1):171-187.
  • Christenson Wick Z, Tetzlaff MR, Krook-Magnuson E. Novel long-range inhibitory nNOS-expressing hippocampal cells. Elife. 2019 Oct 14;8. pii: e46816.
  • Zeidler Z, Brandt-Fontaine M, Leintz C, Krook-Magnuson C, Netoff T, Krook-Magnuson E. Targeting the mouse ventral hippocampus in the intrahippocampal kainic acid model of temporal lobe epilepsy. eNeuro. 2018 Aug 8;5(4).
  • Christenson Wick Z, Krook-Magnuson E. Specificity, versatility, and continual development: The power of optogenetics for epilepsy research. Front Cell Neurosci. 2018 Jun 14;12:151.
  • Krook-Magnuson E. Illuminating seizures: optogenetic approaches to studying networks in epilepsy. J Neurosci Res. 2017;95:2323-2324.
  • Yu W, Krook-Magnuson E. Targeting newly generated granule cells: A double-edged sword. Epilepsy Curr. 2017;17:121-123.
  • Krook-Magnuson E, Gelinas J, Soltesz I, Buzsaki G. Neuroelectronics and bio-optics: Closed-loop technologies in neurological disorders. JAMA Neurology. 2015 Jul 1;72(7):823-9.
  • Christenson Wick Z, Leintz CH, Xamonthiene C, Huang BH, Krook-Magnuson E. Axonal sprouting in commissurally projecting parvalbumin-expressing interneurons. J. Neurosci Res. 2017;95:2336-2344.
  • Zeidler Z, Krook-Magnuson E. One site to rule them all: toward a master regulator of ictal activity. Epilepsy Curr. 2016;16:325-326.
  • Nagaraj V, Lee S, Krook-Magnuson E, Soltesz I, Benquet P, Irazoqui P, Netoff T. Future of seizure prediction and intervention: Closing the loop. J Clin Neurophysiol. 2015;32(3):194-206.
  • Krook-Magnuson E, Armstrong C, Bui A, Lew S, Oijala M, Soltesz I. In vivo evaluation of the dentate gate theory in epilepsy. J Physiol. 2015;593:2379-2398.
  • Krook-Magnuson E, Soltesz I. Beyond the hammer and the scalpel: selective circuit control for the epilepsies. Nat Neurosci. 2015;18:331–338.
  • Krook-Magnuson E, Szabo G, Armstrong C, Oijala M, Soltesz I. Cerebellar directed optogenetic intervention inhibits spontaneous hippocampal seizures in a mouse model of temporal lobe epilepsy eNeuro 2014;1(1). pii: e.2014.
  • Krook-Magnuson E, Ledri M, Soltesz I, Kokaia M. How might novel technologies such as optogenetics lead to better treatments in epilepsy? Adv Exp Med Biol. 2014;813:319-36.
  • Armstrong C, Krook-Magnuson E, Oijala M, Soltesz I. Closed-loop optogenetic intervention in mice. Nat Protoc. 2013;8(8):1475-1493.

Current Graduate Students:

Lauren Glassburn (Neuroscience, University of Minnesota)

Shayne Hastings (Neuroscience, University of Minnesota)

Jessica Froula (Neuroscience, University of Minnesota)

Bethany Stieve (Neuroscience, University of Minnesota).

Former Graduate Students:

Zachary Zeidler (Ph.D. 2020, Neuroscience, University of Minnesota).

Zoe Christenson Wick (Ph.D. 2019, Neuroscience, University of Minnesota).

Picture of Esther Krook-Magnuson